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Aldh2 Gene Detail
 Symbol
Name
ID
Aldh2
aldehyde dehydrogenase 2, mitochondrial
MGI:99600

Nomenclature History
Synonyms Ahd-5, Ahd5
Genetic Map
Chromosome 5
cytoband F-G1
 
Mapping data( 3)
Sequence Map
Chr5:122016036-122043833 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; horse; rat    (Mammalian Orthology)
Protein SuperFamily: NAD-dependent aldehyde dehydrogenase
TreeFam: TF300455
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000023440 VEGA Gene Model | MGI Sequence Detail 27798 C57BL/6J ± Kb
transcript NM_009656 RefSeq | MGI Sequence Detail 2207 C57BL/6
polypeptide P47738 UniProt | EBI | MGI Sequence Detail 519 Not Applicable
For the selected sequences
All sequences(53)
Alleles
and
phenotypes 		All alleles(19) : Targeted, knock-out(1) Gene trapped(18)
Homozygous mutation of this gene results in the absence of oxidation activity in the mitochondria.
Polymorphisms SNPs within 2kb(239 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process metabolic process, oxidation reduction...
Component mitochondrion
Function aldehyde dehydrogenase (NAD) activity, oxidoreductase activity...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression Literature Summary: (4 records)
Data Summary: Assays (1)    Results (8)    Tissues (8)
Theiler Stages: 1,3,4,28
  Assay Type Assays   Results
      RT-PCR 1   8
cDNA source data(608)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(615) Genomic(4) cDNA(609) Primer pair(2)
Microarray probesets(2)
Pathways
putrescine degradation III
fatty acid α-oxidation
β-alanine biosynthesis I
L-lactaldehyde degradation (aerobic)
oxidative ethanol degradation I
dopamine degradation
Other database
links
EC 1.2.1.3
Ensembl Gene Model ENSMUSG00000029455
DoTS DT.101370230, DT.55210725, DT.60118257, DT.94175619
Consensus CDS Project CCDS19638.1
UniGene 284446
DFCI TC1573832, TC1651156
NIA Mouse Gene Index U026686
Entrez Gene 11669
VEGA Gene Model OTTMUSG00000023440
International Mouse Knockout Project Status Aldh2
Protein
domains
InterPro ID Description
IPR015590 Aldehyde dehydrogenase
IPR016160 Aldehyde dehydrogenase, conserved site
IPR016161 Aldehyde/histidinol dehydrogenase
IPR016162 Aldehyde dehydrogenase, N-terminal
Graphical View of Protein Domain Structure
References
(Earliest) J:32774 Algar EM et al., "Aldehyde Dehydrogenase (Ahd)" Mouse News Lett 1985;72():101-102
(Latest) J:145577 Levi BP et al., "Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in the mouse hematopoietic and nervous systems." Blood 2009 Feb 19;113(8):1670-80
All references(27)
Other
accession IDs 		MGD-MRK-1210, MGD-MRK-1217, MGD-MRK-16382
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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