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Cd33 Gene Detail
 Symbol
Name
ID
Cd33
CD33 antigen
MGI:99440


Nomenclature History
Synonyms gp67, Siglec-3
Genetic Map
Chromosome 7
23.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 3)

Sequence Map
Chr7:50783365-50788471 bp, - strand
(From NCBI annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human    (Mammalian Orthology)
Comparative Map (Mouse/Human Cd33 ± 2 cM)
TreeFam: TF332441
Sequences
Representative Sequences Length Strain/Species Flank
genomic 12489 NCBI Gene Model | MGI Sequence Detail 5107 C57BL/6J ± Kb
transcript NM_001111058 RefSeq | MGI Sequence Detail 2571 -
polypeptide Q63994 UniProt | EBI | MGI Sequence Detail 403 Not Applicable
For the selected sequences
All sequences(17)
Alleles
and
phenotypes
All alleles(1) : Targeted, knock-out(1)
Mice homozygous for disruptions in this gene show slight reductions in mean erythrocyte count and hematocrit and increased concentration of blood aspartate aminotransaminase. There is also a hyporesponsiveness to induced peritonitis and a weaker IL-6 response to LPS-induced systemic inflammation.
Polymorphisms RFLP(1) SNPs within 2kb(56 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(6)
Process cell adhesion
Component integral to membrane, membrane...
Function protein binding, sugar binding...
External Resources: MouseFunc
Expression cDNA source data(9)
External Resources: Allen Brain Atlas  GEO 
Molecular
reagents
All nucleic(11) Genomic(1) cDNA(10)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000004609
DoTS DT.99852092
UniGene 140157
DFCI TC1586036
NIA Mouse Gene Index U028478
Entrez Gene 12489
International Mouse Knockout Project Status Cd33
Protein
domains
InterPro ID Description
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like
IPR013106 Immunoglobulin V-set
IPR013162 CD80-like, immunoglobulin C2-set
IPR013783 Immunoglobulin-like fold
Graphical View of Protein Domain Structure
References
(Earliest) J:18452 Tchilian EZ et al., "Molecular cloning of two isoforms of the murine homolog of the myeloid CD33 antigen." Blood 1994 Jun 1;83(11):3188-98
(Latest) J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), "The Transcriptional Landscape of the Mammalian Genome" Science 2005;309(5740):1559-1563
All references(6)
Other
accession IDs
MGD-MRK-16204

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/20/2009
MGI_4.31
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The Jackson Laboratory