Symbol
Name
ID
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Synonyms
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br, Menkes protein, MNK
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Genetic Map
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Sequence Map
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Mammalian
homology
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Sequences
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All sequences(37)
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Alleles
and
phenotypes
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All alleles(84) :
Gene trapped(46)
Spontaneous(23)
Chemically induced(9)
Radiation induced(8)
| Mutations in this gene affect copper metabolism and, depending on the allele, result in abnormal pigmentation, vibrissae, hair, and skeleton. Behavior may be abnormal and defects of collagen and elastin fibers are reported. Some alleles are hemizygous lethal. |
Associated Human Diseases (1)
Alleles Annotated to Human Diseases (3)
Phenotype Images (7)
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Polymorphisms
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All PCR and RFLP(5) :
PCR(1)
RFLP(4)
SNPs within 2kb(301 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
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Expression
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Literature Summary: (7 records)
Data Summary:
Assays (8)
Results (76)
Tissues (15)
Theiler Stages: 23,25,26,28
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Assay Type |
Assays |
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Results |
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Northern blot |
8 |
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76 |
cDNA source data(88)
External Resources:
Allen Brain Atlas
GEO
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Molecular
reagents
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All nucleic(119)
Genomic(6)
cDNA(95)
Primer pair(2)
Other(16)
Microarray probesets(2)
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Other database
links
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Protein
domains
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| InterPro ID |
Description |
| IPR001757 |
ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter |
| IPR001877 |
ATPase 1, copper-transporting |
| IPR005834 |
Haloacid dehalogenase-like hydrolase |
| IPR006121 |
Heavy metal transport/detoxification protein |
| IPR006122 |
Copper ion-binding |
| IPR006403 |
ATPase, P type, cation/copper-transporter |
| IPR006416 |
ATPase, P-type, heavy metal translocating |
| IPR008250 |
ATPase, P-type, ATPase-associated domain |
| IPR017969 |
Heavy-metal-associated, conserved site |
| IPR018303 |
ATPase, P-type phosphorylation site |
Graphical View
of Protein Domain Structure
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References
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(Earliest)
J:24766
Sarvella PA,
"Spontaneous and radiation induced mutations"
Mouse News Lett 1951;5():50
(Latest)
J:153556
Colasante G et al.,
"Arx acts as a regional key selector gene in the ventral telencephalon mainly through its transcriptional repression activity."
Dev Biol 2009 Oct 1;334(1):59-71
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All references(197)
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Other
accession IDs
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MGD-MRK-12339, MGD-MRK-1578, MGD-MRK-16161
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