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Wnt7b Gene Detail
 Symbol
Name
ID
Wnt7b
wingless-related MMTV integration site 7B
MGI:98962


Nomenclature History
Synonyms Wnt-7b
Genetic Map
Chromosome 15
46.9 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 4)

Sequence Map
Chr15:85365877-85412012 bp, - strand
(From Ensembl annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Wnt7b ± 2 cM)
Protein SuperFamily: int-1 transforming protein
TreeFam: TF105310
Sequences
Representative Sequences Length Strain/Species Flank
genomic ENSMUSG00000022382 Ensembl Gene Model | MGI Sequence Detail 46136 C57BL/6J ± Kb
transcript NM_001163634 RefSeq | MGI Sequence Detail 3510 C57BL/6
polypeptide P28047 UniProt | EBI | MGI Sequence Detail 349 Not Applicable
For the selected sequences
All sequences(27)
Alleles
and
phenotypes
All alleles(8) : Targeted, knock-out(2) Targeted, other(5) Gene trapped(1)
Homozygous null embryos die at midgestational stages due to placental abnormalities involving the fusion of the chorion and allantois. Mice homozygous for a truncated allele display neonatal lethality, respiratory failure, and lung hemorrhage.
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(176 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process cell-cell signaling, cellular metabolic process...
Component extracellular region, proteinaceous extracellular matrix...
Function protein binding, receptor binding...
External Resources: FuncBase
Expression Literature Summary: (102 records)
Data Summary: Assays (26)    Results (307)    Tissues (173)    Images (76)
Theiler Stages: 1,2,3,4,5,8,9,11,13,15,16,17,19,20,21,22,23,24,26,28
  Assay Type Assays   Results
      Western blot 1   1
      RT-PCR 7   32
      RNA in situ 16   267
      Immunohistochemistry 1   5
      RNase protection 1   2
cDNA source data(55)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents
All nucleic(74) cDNA(59) Primer pair(10) Other(5) Antibodies(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000022382
DoTS DT.101725892, DT.530872, DT.97386548
Consensus CDS Project CCDS37171.1
UniGene 306946
DFCI TC1580998, TC1597352, TC1602291
NIA Mouse Gene Index U036500
Entrez Gene 22422
International Mouse Knockout Project Status Wnt7b
Protein
domains
InterPro ID Description
IPR005816 Secreted growth factor Wnt protein
IPR005817 Wnt superfamily
IPR013300 Wnt-7 protein
IPR018161 Secreted growth factor Wnt protein, conserved site
Graphical View of Protein Domain Structure
References
(Earliest) J:10971 Gavin BJ et al., "Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development." Genes Dev 1990 Dec;4(12B):2319-32
(Latest) J:155332 Fotaki V et al., "Loss of Wnt8b has no overt effect on hippocampus development but leads to altered Wnt gene expression levels in dorsomedial telencephalon." Dev Dyn 2010 Jan;239(1):284-96
All references(126)
Other
accession IDs
MGD-MRK-15447, MGD-MRK-15457

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
02/06/2010
MGI_4.32
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The Jackson Laboratory