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Wnt5a Gene Detail
 Symbol
Name
ID
Wnt5a
wingless-related MMTV integration site 5A
MGI:98958

Nomenclature History
Synonyms 8030457G12Rik, Wnt-5a
Genetic Map
Chromosome 14
7.8 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 12)

Sequence Map
Chr14:29317936-29340633 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Wnt5a ± 2 cM)
Protein SuperFamily: int-1 transforming protein
TreeFam: TF105310
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000021010 VEGA Gene Model | MGI Sequence Detail 22698 C57BL/6J ± Kb
transcript NM_009524 RefSeq | MGI Sequence Detail 4273 C57BL/6
polypeptide P22725 UniProt | EBI | MGI Sequence Detail 380 Not Applicable
For the selected sequences
All sequences(22)
Alleles
and
phenotypes 		All alleles(1) : Targeted, knock-out(1)
Homozygous mutants exhibit caudal truncation with shortened anterior-posterior axis, truncation of the snout, tongue and mandible, short fore- and hindlimbs, which lack digits, absent genital tubercle and lung abnormalities. Mutants die perinatally.
Associated Human Diseases (1)   Alleles Annotated to Human Diseases (1)  
Polymorphisms RFLP(4) SNPs within 2kb(109 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process cartilage development, cell differentiation...
Component extracellular region, proteinaceous extracellular matrix...
Function protein binding, receptor binding...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression Literature Summary: (139 records)
Data Summary: Assays (40)    Results (525)    Tissues (310)    Images (88)
Theiler Stages: 1,2,3,4,5,8,9,11,13,14,15,17,18,19,20,21,22,23,24,25,26,28
  Assay Type Assays   Results
      RT-PCR 18   249
      RNA in situ 21   270
      Immunohistochemistry 1   6
cDNA source data(18)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(50) Genomic(1) cDNA(22) Primer pair(20) Other(7) Antibodies(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000021994
DoTS DT.101725912
Consensus CDS Project CCDS26888.1
DFCI TC1580129, TC1606400, TC1614372
NIA Mouse Gene Index U043385
Entrez Gene 22418
VEGA Gene Model OTTMUSG00000021010
International Mouse Knockout Project Status Wnt5a
Protein
domains
InterPro ID Description
IPR005816 Secreted growth factor Wnt protein
IPR005817 Wnt superfamily
IPR018161 Secreted growth factor Wnt protein, conserved site
Graphical View of Protein Domain Structure
References
(Earliest) J:10971 Gavin BJ et al., "Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development." Genes Dev 1990 Dec;4(12B):2319-32
(Latest) J:156508 Sato A et al., "Wnt5a regulates distinct signalling pathways by binding to Frizzled2." EMBO J 2010 Jan 6;29(1):41-54
All references(177)
Other
accession IDs 		MGD-MRK-15443, MGD-MRK-15453, MGI:1924815
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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