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Wnt3a Gene Detail
 Symbol
Name
ID
Wnt3a
wingless-related MMTV integration site 3A
MGI:98956


Nomenclature History
Synonyms Wnt-3a
Genetic Map
Chromosome 11
32.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 27)

Sequence Map
Chr11:59061535-59104254 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Wnt3a ± 2 cM)
Protein SuperFamily: int-1 transforming protein
TreeFam: TF105310
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000005791 VEGA Gene Model | MGI Sequence Detail 42720 C57BL/6J ± Kb
transcript NM_009522 RefSeq | MGI Sequence Detail 2791 C57BL/6
polypeptide P27467 UniProt | EBI | MGI Sequence Detail 352 Not Applicable
For the selected sequences
All sequences(12)
Alleles
and
phenotypes
All alleles(9) : Targeted, knock-out(2) Targeted, other(1) Gene trapped(5) Spontaneous(1)
Homozygous null mutants die at embryonic day 10.5-12.5 with failed development of caudal somites, notochord and structures rostral to hindlimbs. Homozygotes for a hypomorphic allele have vertebral defects and a short tail due to loss of caudal vertebrae.
Phenotype Images (1)  
Polymorphisms RFLP(1) SNPs within 2kb(178 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(33)
Process anterior/posterior pattern formation, axonogenesis...
Component extracellular region, extracellular space...
Function protein binding, receptor binding...
External Resources: MouseFunc
Expression Literature Summary: (140 records)
Data Summary: Assays (37)    Results (384)    Tissues (218)    Images (64)
Theiler Stages: 1,2,3,4,5,8,9,11,12,13,14,15,16,17,18,19,20,21,22,23,24,28
  Assay Type Assays   Results
      RT-PCR 11   83
      RNA in situ 24   288
      Northern blot 1   11
      RNase protection 1   2
cDNA source data(13)
External Resources: Allen Brain Atlas  GENSAT  GEO 
Molecular
reagents
All nucleic(36) Genomic(3) cDNA(14) Primer pair(12) Other(7) Antibodies(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000009900
DoTS DT.60102684
UniGene 1367
DFCI TC1589485
NIA Mouse Gene Index U032842
Entrez Gene 22416
VEGA Gene Model OTTMUSG00000005791
International Mouse Knockout Project Status Wnt3a
Protein
domains
InterPro ID Description
IPR005816 Secreted growth factor Wnt protein
IPR005817 Wnt superfamily
IPR009141 Wnt-3 protein
IPR018161 Secreted growth factor Wnt protein, conserved site
Graphical View of Protein Domain Structure
References
(Earliest) J:13062 HESTON WE, "The 'vestigial tail' mouse; a new recessive mutation." J Hered 1951 Mar-Apr;42(2):71-4
(Latest) J:153209 Tissir F et al., "DeltaNp73 regulates neuronal survival in vivo." Proc Natl Acad Sci U S A 2009 Sep 29;106(39):16871-6
All references(225)
Other
accession IDs
MGD-MRK-15417, MGD-MRK-15441, MGD-MRK-15451

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/20/2009
MGI_4.31
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The Jackson Laboratory