Symbol
Name
ID
|
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Genetic Map
|
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Sequence Map
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Mammalian
homology
|
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Sequences
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All sequences(58)
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Alleles
and
phenotypes
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All alleles(5) :
Targeted, knock-out(3)
Targeted, other(2)
| Homozygous null mutants exhibit defective T cell maturation, interleukin-2 production, and cell cycle progression. Immunoglobulin class switching is also impaired and attributed to defective T cell help. |
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Polymorphisms
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RFLP(6)
SNPs within 2kb(127 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
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Expression
|
Literature Summary: (3 records)
Data Summary:
Assays (1)
Results (21)
Tissues (5)
Theiler Stages: 15,19
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Assay Type |
Assays |
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Results |
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RT-PCR |
1 |
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21 |
cDNA source data(42)
External Resources:
Allen Brain Atlas
GEO
ArrayExpress
|
Molecular
reagents
|
All nucleic(45)
cDNA(42)
Primer pair(1)
Other(2)
Antibodies(1)
Microarray probesets(2)
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Other database
links
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| Ensembl Gene Model |
ENSMUSG00000034116 |
| DoTS |
DT.101347811, DT.101380638, DT.101380639, DT.110559645, DT.97366427, DT.99863524 |
| Consensus CDS Project |
CCDS28931.1 |
| UniGene |
248172 |
| PDB |
1F5X, 1GCP, 1GCQ, 1K1Z, 2KBT, 2VRW |
| DFCI |
TC1575273, TC1594756, TC1596173, TC1660670 |
| NIA Mouse Gene Index |
U018150 |
| Entrez Gene |
22324 |
| International Mouse Knockout Project Status |
Vav1 |
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Protein
domains
|
Graphical View
of Protein Domain Structure
|
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References
|
(Earliest)
J:18384
Katzav S et al.,
"vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells."
EMBO J 1989 Aug;8(8):2283-90
(Latest)
J:155962
Ruiz S et al.,
"The use of knockout mice reveals a synergistic role of the Vav1 and Rasgrf2 gene deficiencies in lymphomagenesis and metastasis."
PLoS One 2009;4(12):e8229
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All references(110)
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Other
accession IDs
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MGD-MRK-15381
|
Analysis Tools
MGI BioMart
