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Tpmt Gene Detail
 Symbol
Name
ID
Tpmt
thiopurine methyltransferase
MGI:98812

Nomenclature History
Genetic Map
Chromosome 13
28.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 6)

Sequence Map
Chr13:47120539-47140106 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Tpmt ± 2 cM)
Protein SuperFamily: thiopurine S-methyltransferase
TreeFam: TF328951
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000024764 VEGA Gene Model | MGI Sequence Detail 19568 C57BL/6J ± Kb
transcript NM_016785 RefSeq | MGI Sequence Detail 2715 C57BL/6
polypeptide O55060 UniProt | EBI | MGI Sequence Detail 240 Not Applicable
For the selected sequences
All sequences(35)
Alleles
and
phenotypes 		All alleles(5) : Targeted, knock-out(1) Gene trapped(4)
Associated Human Diseases (1)   Alleles Annotated to Human Diseases (1)  
Polymorphisms SNPs within 2kb(109 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process metabolic process
Component cytoplasm
Function methyltransferase activity, thiopurine S-methyltransferase activity...
External Resources: FuncBase
Expression cDNA source data(32)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(34) cDNA(34)
Microarray probesets(3)
Other database
links
EC 2.1.1.67
Ensembl Gene Model ENSMUSG00000021376
DoTS DT.101366425, DT.487113, DT.55275414, DT.94232342
Consensus CDS Project CCDS26488.1
UniGene 10169
PDB 2GB4, 3BGD, 3BGI
DFCI TC1582849, TC1600751
NIA Mouse Gene Index U034740
Entrez Gene 22017
VEGA Gene Model OTTMUSG00000024764
International Mouse Knockout Project Status Tpmt
Protein
domains
InterPro ID Description
IPR008854 Thiopurine S-methyltransferase
IPR016822 Thiopurine S-methyltransferase, subgroup
Graphical View of Protein Domain Structure
References
(Earliest) J:8633 Otterness DM et al., "Mouse thiopurine methyltransferase pharmacogenetics: monogenic inheritance." J Pharmacol Exp Ther 1987 Mar;240(3):817-24
(Latest) J:121737 Hartford C et al., "Differential effects of targeted disruption of thiopurine methyltransferase on mercaptopurine and thioguanine pharmacodynamics." Cancer Res 2007 May 15;67(10):4965-72
All references(10)
Other
accession IDs 		MGD-MRK-15208, MGI:2145410
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
Web browser compatibility 		The Jackson Laboratory