Symbol
Name
ID
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Synonyms
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D11Bwg1104e, TIMP-2, Timp-2
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Genetic Map
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Sequence Map
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Mammalian
homology
|
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Sequences
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All sequences(47)
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Alleles
and
phenotypes
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All alleles(7) :
Targeted, knock-out(2)
Gene trapped(5)
| Homozygotes for targeted null mutations exhibit impaired activation of pro-matrix metalloproteinase-2, but appear phenotypically normal. |
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Polymorphisms
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RFLP(1)
SNPs within 2kb(73 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
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Expression
|
Literature Summary: (36 records)
Data Summary:
Assays (10)
Results (68)
Tissues (41)
Images (7)
Theiler Stages: 1,2,3,4,19,20,21,22,23,25,26,28
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Assay Type |
Assays |
|
Results |
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Western blot |
3 |
|
30 |
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RT-PCR |
5 |
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23 |
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RNA in situ |
1 |
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3 |
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Northern blot |
1 |
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12 |
cDNA source data(294)
External Resources:
Allen Brain Atlas
GENSAT
GEO
|
Molecular
reagents
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All nucleic(302)
Genomic(1)
cDNA(295)
Primer pair(5)
Other(1)
Antibodies(1)
Microarray probesets(4)
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Other database
links
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Protein
domains
|
| InterPro ID |
Description |
| IPR001134 |
Netrin domain |
| IPR001820 |
Proteinase inhibitor I35, tissue inhibitor of metalloproteinase |
| IPR008993 |
TIMP-like, OB-fold |
| IPR015613 |
Tissue inhibitor of metalloprotease 2 |
Graphical View
of Protein Domain Structure
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References
|
(Earliest)
J:1243
Shimizu S et al.,
"Cloning and sequencing of the cDNA encoding a mouse tissue inhibitor of metalloproteinase-2."
Gene 1992 May 15;114(2):291-2
(Latest)
J:153449
Sabeh F et al.,
"Secreted versus membrane-anchored collagenases: relative roles in fibroblast-dependent collagenolysis and invasion."
J Biol Chem 2009 Aug 21;284(34):23001-11
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All references(71)
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Other
accession IDs
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MGD-MRK-15111, MGD-MRK-15113, MGD-MRK-34056, MGI:106364
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