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Tec Gene Detail
 Symbol
Name
ID
Tec
tec protein tyrosine kinase
MGI:98662

Nomenclature History
Genetic Map
Chromosome 5
41.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 8)

Sequence Map
Chr5:73146957-73259722 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Tec ± 2 cM)
Protein SuperFamily: tyrosine-protein kinase, TEC type
TreeFam: TF315363
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000025011 VEGA Gene Model | MGI Sequence Detail 112766 C57BL/6J ± Kb
transcript NM_001113460 RefSeq | MGI Sequence Detail 2656 C57BL/6
polypeptide P24604 UniProt | EBI | MGI Sequence Detail 630 Not Applicable
For the selected sequences
All sequences(53)
Alleles
and
phenotypes 		All alleles(3) : Targeted, knock-out(1) Gene trapped(2)
Associated Human Diseases (1)   Alleles Annotated to Human Diseases (1)  
Polymorphisms RFLP(3) SNPs within 2kb(880 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process intracellular signaling cascade, protein amino acid phosphorylation...
Component cytoplasm
Function ATP binding, kinase activity...
External Resources: FuncBase
Expression Literature Summary: (6 records)
Data Summary: Assays (8)    Results (51)    Tissues (15)
Theiler Stages: 13,17,24,28
  Assay Type Assays   Results
      RNA in situ 1   4
      RNase protection 7   47
cDNA source data(51)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(58) Genomic(2) cDNA(51) Primer pair(1) Other(4)
Microarray probesets(1)
Other database
links
EC 2.7.10.2
Ensembl Gene Model ENSMUSG00000029217
DoTS DT.101137569, DT.101302026, DT.101377735, DT.101725013, DT.110648639, DT.529331, DT.91327773, DT.99840872
UniGene 319581
PDB 1GL5
DFCI TC1579177, TC1591839, TC1592566, TC1672147
Entrez Gene 21682
VEGA Gene Model OTTMUSG00000025011
International Mouse Knockout Project Status Tec
Protein
domains
InterPro ID Description
IPR000719 Protein kinase, catalytic domain
IPR000980 SH2 motif
IPR001245 Tyrosine-protein kinase, catalytic domain
IPR001452 Src homology-3 domain
IPR001562 Zinc finger, Btk motif
IPR001849 Pleckstrin homology
IPR008266 Tyrosine-protein kinase, active site
IPR011009 Protein kinase-like domain
IPR011993 Pleckstrin homology-type
IPR017441 Protein kinase, ATP binding site
IPR020473 Src homology-3, region
IPR020635 Tyrosine-protein kinase, subgroup, catalytic domain
IPR020685 Tyrosine-protein kinase
IPR020755 Tyrosine-protein kinase, non-receptor Txk/Tec
Graphical View of Protein Domain Structure
References
(Earliest) J:22689 Wilks AF et al., "The application of the polymerase chain reaction to cloning members of the protein tyrosine kinase family." Gene 1989 Dec 21;85(1):67-74
(Latest) J:154200 Schmidt U et al., "The protein tyrosine kinase Tec regulates mast cell function." Eur J Immunol 2009 Aug 17;39(11):3228-3238
All references(33)
Other
accession IDs 		MGD-MRK-14989
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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