Symbol
Name
ID
|
|
|
Synonyms
|
bHLHa17, Scl, SCL/tal-1
|
|
Genetic Map
|
|
|
Sequence Map
|
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Mammalian
homology
|
|
|
Sequences
|
All sequences(20)
|
Alleles
and
phenotypes
|
All alleles(7) :
Targeted, knock-out(2)
Targeted, other(5)
| Homozygous targeted null mutants show retarded growth, edema, lack yolk sac hematopoiesis and die at embryonic day 9.5-10.5. Conditional mutants show loss of megakaryocyte and erhythrocyte progenitors resulting in low hematocrit and platelet count. |
Phenotype Images (1)
|
|
Polymorphisms
|
RFLP(2)
SNPs within 2kb(30 from dbSNP Build 128)
|
Gene Ontology
(GO)
classifications
|
|
|
Expression
|
Literature Summary: (41 records)
Data Summary:
Assays (19)
Results (184)
Tissues (116)
Images (18)
Theiler Stages: 9,10,11,12,13,14,15,16,17,18,19,20,21,22,28
| |
Assay Type |
Assays |
|
Results |
| |
Western blot |
1 |
|
4 |
| |
RT-PCR |
10 |
|
102 |
| |
RNA in situ |
5 |
|
62 |
| |
Immunohistochemistry |
1 |
|
3 |
| |
Northern blot |
2 |
|
13 |
cDNA source data(28)
External Resources:
Allen Brain Atlas
GEO
|
Molecular
reagents
|
All nucleic(44)
Genomic(4)
cDNA(28)
Primer pair(9)
Other(3)
Antibodies(3)
Microarray probesets(2)
|
Other database
links
|
|
Protein
domains
|
| InterPro ID |
Description |
| IPR001092 |
Helix-loop-helix DNA-binding domain |
| IPR011598 |
Helix-loop-helix DNA-binding |
Graphical View
of Protein Domain Structure
|
|
References
|
(Earliest)
J:8017
Blackwell JM et al.,
"Response of BALB/c mice to leishmanial infection."
Curr Top Microbiol Immunol 1985;122():97-106
(Latest)
J:153551
Bockamp E et al.,
"In vivo fate mapping with SCL regulatory elements identifies progenitors for primitive and definitive hematopoiesis in mice."
Mech Dev 2009 Oct;126(10):863-72
|
All references(116)
|
Other
accession IDs
|
MGD-MRK-14313, MGD-MRK-14708
|
