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Src Gene Detail
 Symbol
Name
ID
Src
Rous sarcoma oncogene
MGI:98397


Nomenclature History
Synonyms pp60c-src
Genetic Map
Chromosome 2
89.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 36)

Sequence Map
Chr2:157244180-157297598 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; cat, domestic; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Src ± 2 cM)
Protein SuperFamily: tyrosine-protein kinase, proto-oncogene SRC type
TreeFam: TF351634
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000016179 VEGA Gene Model | MGI Sequence Detail 53419 C57BL/6J ± Kb
transcript NM_009271 RefSeq | MGI Sequence Detail 3887 C57BL/6
polypeptide P05480 UniProt | EBI | MGI Sequence Detail 541 Not Applicable
For the selected sequences
All sequences(40)
Alleles
and
phenotypes
All alleles(67) : Targeted, knock-out(1) Gene trapped(66)
Homozygotes for a targeted null mutation exhibit growth retardation, failure of tooth eruption, osteopetrosis with lack of secondary bone resorption, and lethality at 3-4 weeks.
Polymorphisms RFLP(12) SNPs within 2kb(246 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(18)
Process branching involved in mammary gland duct morphogenesis, cell migration...
Function ATP binding, kinase activity...
External Resources: MouseFunc
Expression Literature Summary: (18 records)
Data Summary: Assays (3)    Results (105)    Tissues (52)    Images (15)
Theiler Stages: 22,23,24,26,28
  Assay Type Assays   Results
      RT-PCR 2   92
      RNA in situ 1   13
cDNA source data(90)
External Resources: Allen Brain Atlas  GENSAT  GEO 
Molecular
reagents
All nucleic(104) Genomic(7) cDNA(93) Primer pair(1) Other(3)
Microarray probesets(3)
Other database
links
EC 2.7.10.2
Ensembl Gene Model ENSMUSG00000027646
DoTS DT.101359821, DT.101365231, DT.522608
UniGene 22845
DFCI TC1578172, TC1598566
NIA Mouse Gene Index U002739
Entrez Gene 20779
VEGA Gene Model OTTMUSG00000016179
International Mouse Knockout Project Status Src
Protein
domains
InterPro ID Description
IPR000719 Protein kinase, catalytic domain
IPR000980 SH2 motif
IPR001245 Tyrosine-protein kinase, catalytic domain
IPR001452 Src homology-3 domain
IPR008266 Tyrosine-protein kinase, active site
IPR011009 Protein kinase-like domain
IPR017441 Protein kinase, ATP binding site
IPR020473 Src homology-3, region
IPR020635 Tyrosine-protein kinase, subgroup, catalytic domain
IPR020744 Tyrosine-protein kinase, non-receptor Src
Graphical View of Protein Domain Structure
References
(Earliest) J:5972 Collett MS et al., "Protein kinase activity associated with the avian sarcoma virus src gene product." Proc Natl Acad Sci U S A 1978 Apr;75(4):2021-4
(Latest) J:153843 Yi Z et al., "A novel role for c-Src and STAT3 in apoptotic cell-mediated MerTK-dependent immunoregulation of dendritic cells." Blood 2009 Oct 8;114(15):3191-8
All references(159)
Other
accession IDs
MGD-MRK-14556, MGI:2139334

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/20/2009
MGI_4.31
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The Jackson Laboratory