Symbol
Name
ID
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Synonyms
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2900005C20Rik, Cek8, Hek8, rb, Sek, Sek1, Tyro1
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Genetic Map
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Sequence Map
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Mammalian
homology
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Sequences
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All sequences(27)
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Alleles
and
phenotypes
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All alleles(57) :
Targeted, knock-out(2)
Targeted, other(8)
Gene trapped(45)
Spontaneous(2)
| Mutants are known for their "hopping gait". Homozygotes for targeted null mutations show loss of limb alternation in locomotion and axon guidance defects of the corticospinal tract within medulla and spinal cord, resulting in aberrant midline projections. Heterozygotes show less severe phenotype. |
Phenotype Images (2)
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Polymorphisms
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SNPs within 2kb(669 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
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Expression
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Literature Summary: (120 records)
Data Summary:
Assays (36)
Results (204)
Tissues (85)
Images (81)
Theiler Stages: 11,12,13,14,15,16,17,19,20,21,22,23,24,28
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Assay Type |
Assays |
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Results |
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Western blot |
2 |
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4 |
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RT-PCR |
4 |
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12 |
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RNA in situ |
26 |
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151 |
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Immunohistochemistry |
3 |
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25 |
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Northern blot |
1 |
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12 |
cDNA source data(98)
External Resources:
Allen Brain Atlas
GENSAT
GEO
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Molecular
reagents
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All nucleic(116)
cDNA(104)
Primer pair(2)
Other(10)
Antibodies(4)
Microarray probesets(3)
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Other database
links
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Protein
domains
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| InterPro ID |
Description |
| IPR000719 |
Protein kinase, catalytic domain |
| IPR001090 |
Ephrin receptor, ligand binding |
| IPR001245 |
Tyrosine-protein kinase, catalytic domain |
| IPR001426 |
Tyrosine-protein kinase, receptor class V, conserved site |
| IPR001660 |
Sterile alpha motif SAM |
| IPR003961 |
Fibronectin, type III |
| IPR003962 |
Fibronectin, type III subdomain |
| IPR008266 |
Tyrosine-protein kinase, active site |
| IPR008957 |
Fibronectin, type III-like fold |
| IPR008979 |
Galactose-binding domain-like |
| IPR010993 |
Sterile alpha motif homology |
| IPR011009 |
Protein kinase-like domain |
| IPR011510 |
Sterile alpha motif homology 2 |
| IPR013761 |
Sterile alpha motif-type |
| IPR016257 |
Tyrosine-protein kinase, ephrin receptor |
| IPR017441 |
Protein kinase, ATP binding site |
| IPR020635 |
Tyrosine-protein kinase, subgroup, catalytic domain |
Graphical View
of Protein Domain Structure
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References
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(Earliest)
J:3319
Gilardi-Hebenstreit P et al.,
"An Eph-related receptor protein tyrosine kinase gene segmentally expressed in the developing mouse hindbrain [published erratum appears in Oncogene 1993 Apr;8(4):1103]"
Oncogene 1992 Dec;7(12):2499-506
(Latest)
J:152861
Skuntz S et al.,
"Lack of the mesodermal homeodomain protein MEOX1 disrupts sclerotome polarity and leads to a remodeling of the cranio-cervical joints of the axial skeleton."
Dev Biol 2009 Aug 15;332(2):383-95
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All references(169)
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Other
accession IDs
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MGD-MRK-14356, MGD-MRK-38166, MGI:109122, MGI:1920161, MGI:2138218
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