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Ren1 Gene Detail
 Symbol
Name
ID
Ren1
renin 1 structural
MGI:97898


Nomenclature History
STS D1Mit31
Synonyms Ren, Ren-1, Ren-A, Ren1c, Ren1d, Rn-1, Rnr
Genetic Map
Chromosome 1
69.9 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 32)

Sequence Map
Chr1:135247087-135256902 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Ren1 ± 2 cM)
Protein SuperFamily: Pepsin
TreeFam: TF314990
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000021617 VEGA Gene Model | MGI Sequence Detail 9816 C57BL/6J ± Kb
transcript NM_031192 RefSeq | MGI Sequence Detail 1420 C57BL/6
polypeptide P06281 UniProt | EBI | MGI Sequence Detail 402 Not Applicable
For the selected sequences
All sequences(30)
Alleles
and
phenotypes
All alleles(7) : Targeted, knock-out(4) Targeted, other(3)
Phenotype Images (1)  
Polymorphisms All PCR and RFLP(11) : PCR(2) RFLP(9) SNPs within 2kb(222 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(14)
Process angiotensin maturation, cell maturation...
Component extracellular region, extracellular space...
Function aspartic-type endopeptidase activity, hydrolase activity...
External Resources: MouseFunc
Expression Literature Summary: (15 records)
Data Summary: Assays (9)    Results (77)    Tissues (28)    Images (6)
Theiler Stages: 18,20,21,22,23,26,28
  Assay Type Assays   Results
      RT-PCR 1   44
      RNA in situ 2   11
      Northern blot 6   22
cDNA source data(5)
External Resources: Allen Brain Atlas  GEO 
Molecular
reagents
All nucleic(36) Genomic(16) cDNA(15) Primer pair(3) Other(2)
Microarray probesets(2)
Other database
links
EC 3.4.23.15
Ensembl Gene Model ENSMUSG00000070645
DoTS DT.110906117, DT.91403692
Entrez Gene 19701
VEGA Gene Model OTTMUSG00000021617
International Mouse Knockout Project Status Ren1
Protein
domains
InterPro ID Description
IPR001461 Peptidase A1
IPR001969 Peptidase aspartic, active site
IPR009007 Peptidase aspartic, catalytic
IPR012848 Propeptide, peptidase A1
Graphical View of Protein Domain Structure
References
(Earliest) J:5794 Wilson CM et al., "Genetic control of renin activity in the submaxillary gland of the mouse." Proc Natl Acad Sci U S A 1977 Mar;74(3):1185-9
(Latest) J:152122 Kurtz L et al., "Connexin expression in renin-producing cells." J Am Soc Nephrol 2009 Mar;20(3):506-12
All references(117)
Other
accession IDs
MGD-MRK-13833, MGD-MRK-13834, MGD-MRK-13836, MGD-MRK-13838, MGD-MRK-13917, MGD-MRK-13951, MGI:2138723

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/20/2009
MGI_4.31
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The Jackson Laboratory