Symbol
Name
ID
|
|
|
Synonyms
|
pRb, Rb, Rb-1
|
|
Genetic Map
|
|
|
Sequence Map
|
|
Mammalian
homology
|
|
|
Sequences
|
All sequences(25)
|
Alleles
and
phenotypes
|
All alleles(40) :
Targeted, knock-out(9)
Targeted, other(11)
Gene trapped(20)
| Homozygotes for targeted mutations exhibit abnormalities of the neuronal and hematopoietic systems and die in utero. Heterozygotes may develop pituitary tumors associated with loss of the normal allele. |
Associated Human Diseases (2)
Alleles Annotated to Human Diseases (2)
|
|
Polymorphisms
|
RFLP(6)
SNPs within 2kb(858 from dbSNP Build 128)
|
Gene Ontology
(GO)
classifications
|
|
|
Expression
|
Literature Summary: (54 records)
Data Summary:
Assays (23)
Results (127)
Tissues (46)
Images (8)
Theiler Stages: 6,7,9,11,13,14,15,17,19,20,21,22,23,24,25,26,28
| |
Assay Type |
Assays |
|
Results |
| |
Western blot |
15 |
|
72 |
| |
RT-PCR |
1 |
|
2 |
| |
Northern blot |
7 |
|
53 |
cDNA source data(79)
External Resources:
Allen Brain Atlas
GENSAT
GEO
|
Molecular
reagents
|
All nucleic(89)
Genomic(5)
cDNA(82)
Primer pair(1)
Other(1)
Antibodies(6)
Microarray probesets(2)
|
Other database
links
|
|
Protein
domains
|
Graphical View
of Protein Domain Structure
|
|
References
|
(Earliest)
J:22884
Friend SH et al.,
"A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma."
Nature 1986 Oct 16-22;323(6089):643-6
(Latest)
J:154066
Nalam RL et al.,
"Retinoblastoma protein plays multiple essential roles in the terminal differentiation of Sertoli cells."
Mol Endocrinol 2009 Nov;23(11):1900-13
|
All references(359)
|
Other
accession IDs
|
MGD-MRK-13784, MGD-MRK-13785
|
