Symbol
Name
ID
|
|
|
Synonyms
|
B220, CD45, Ly-5, Lyt-4, T200
|
|
Genetic Map
|
|
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Sequence Map
|
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Mammalian
homology
|
|
|
Sequences
|
All sequences(48)
|
Alleles
and
phenotypes
|
All alleles(7) :
Targeted, knock-out(3)
Targeted, other(2)
Chemically induced(2)
| Homozygous null mutants have defective T-cell maturation. Mice carrying an engineered point mutation exhibit lymphoproliferation and autoimmunity that leads to premature death. |
Associated Human Diseases (1)
Alleles Annotated to Human Diseases (1)
|
|
Polymorphisms
|
All PCR and RFLP(13) :
PCR(1)
RFLP(12)
SNPs within 2kb(700 from dbSNP Build 128)
|
Gene Ontology
(GO)
classifications
|
|
|
Expression
|
Literature Summary: (62 records)
Data Summary:
Assays (4)
Results (15)
Tissues (10)
Images (4)
Theiler Stages: 15,16,18,19,20,21,28
| |
Assay Type |
Assays |
|
Results |
| |
RT-PCR |
1 |
|
2 |
| |
Immunohistochemistry |
3 |
|
13 |
cDNA source data(234)
External Resources:
Allen Brain Atlas
GENSAT
GEO
|
Molecular
reagents
|
All nucleic(254)
Genomic(16)
cDNA(234)
Primer pair(3)
Other(1)
Antibodies(3)
Microarray probesets(2)
|
Other database
links
|
| EC |
3.1.3.48 |
| Ensembl Gene Model |
ENSMUSG00000026395 |
| DoTS |
DT.101192522, DT.101254812, DT.101311356, DT.101319236, DT.101335838, DT.101367407, DT.94206213 |
| UniGene |
391573 |
| DFCI |
TC1573000, TC1592704, TC1605209, TC1614008, TC1666888 |
| NIA Mouse Gene Index |
U021829 |
| Entrez Gene |
19264 |
| International Mouse Knockout Project Status |
Ptprc |
|
Protein
domains
|
| InterPro ID |
Description |
| IPR000242 |
Protein-tyrosine phosphatase, receptor/non-receptor type |
| IPR000387 |
Dual-specific/protein-tyrosine phosphatase, conserved region |
| IPR003961 |
Fibronectin, type III |
| IPR008957 |
Fibronectin, type III-like fold |
| IPR016130 |
Protein-tyrosine phosphatase, active site |
| IPR016335 |
Leukocyte common antigen |
Graphical View
of Protein Domain Structure
|
|
References
|
(Earliest)
J:12077
Komuro K et al.,
"Ly-5: a new lymphocyte antigen system."
Immunogenetics 1975;1():452-456
(Latest)
J:150308
Vondenhoff MF et al.,
"LTbetaR signaling induces cytokine expression and up-regulates lymphangiogenic factors in lymph node anlagen."
J Immunol 2009 May 1;182(9):5439-45
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All references(252)
|
Other
accession IDs
|
MGD-MRK-11992, MGD-MRK-12076, MGD-MRK-13679, MGD-MRK-1864, MGI:3584395
|
