Symbol
Name
ID
|
|
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STS
|
D2Hss1
|
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Synonyms
|
3110043I21Rik, mKIAA0581
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Genetic Map
|
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Sequence Map
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Mammalian
homology
|
|
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Sequences
|
All sequences(45)
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Alleles
and
phenotypes
|
All alleles(2) :
Targeted, knock-out(1)
Transgenic(1)
| Homozygotes for a targeted null mutation exhibit spontaneous seizures and high mortality around 3 weeks of age. Mutant males show exhibit sperm with a reduced acrosome reaction rate and fertilizing capacity in vitro and decreased fertility in vivo. |
Associated Human Diseases (2)
Alleles Annotated to Human Diseases (1)
|
|
Polymorphisms
|
RFLP(4)
SNPs within 2kb(3872 from dbSNP Build 128)
|
Gene Ontology
(GO)
classifications
|
|
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Expression
|
Literature Summary: (3 records)
Data Summary:
Assays (2)
Results (140)
Tissues (139)
Images (19)
Theiler Stages: 22,23,28
| |
Assay Type |
Assays |
|
Results |
| |
RT-PCR |
1 |
|
46 |
| |
RNA in situ |
1 |
|
94 |
cDNA source data(42)
External Resources:
Allen Brain Atlas
GENSAT
GEO
ArrayExpress
|
Molecular
reagents
|
All nucleic(51)
Genomic(4)
cDNA(43)
Primer pair(2)
Other(2)
Microarray probesets(4)
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Pathways
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Other database
links
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Protein
domains
|
| InterPro ID |
Description |
| IPR000008 |
C2 calcium-dependent membrane targeting |
| IPR000909 |
Phospholipase C, phosphatidylinositol-specific , X domain |
| IPR001192 |
Phospholipase C, phosphoinositol-specific, C-terminal (PLC) |
| IPR001711 |
Phospholipase C, phosphatidylinositol-specific, Y domain |
| IPR008973 |
C2 calcium/lipid-binding domain, CaLB |
| IPR009535 |
Protein of unknown function DUF1154 |
| IPR011992 |
EF-hand-like domain |
| IPR014815 |
PLC-beta, C-terminal |
| IPR015359 |
Phospholipase C, phosphoinositol-specific, EF-hand-like |
| IPR016280 |
Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta |
| IPR017946 |
PLC-like phosphodiesterase, TIM beta/alpha-barrel domain |
| IPR018029 |
C2 membrane targeting protein |
Graphical View
of Protein Domain Structure
|
|
References
|
(Earliest)
J:30483
Hempel WM et al.,
"Expression of phospholipase C isozymes by murine B lymphocytes."
J Immunol 1991 Jun 1;146(11):3713-20
(Latest)
J:151070
McOmish CE et al.,
"Phospholipase C-beta1 knockout mice exhibit endophenotypes modeling schizophrenia which are rescued by environmental enrichment and clozapine administration."
Mol Psychiatry 2008 Jul;13(7):661-72
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All references(34)
|
Other
accession IDs
|
MGD-MRK-13351, MGI:1920444, MGI:2138844
|
Analysis Tools
MGI BioMart
