Symbol
Name
ID
|
|
|
STS
|
D14Nds1
|
|
Synonyms
|
u-PA, uPA, urokinase-type plasminogen activator
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Genetic Map
|
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Sequence Map
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Mammalian
homology
|
|
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Sequences
|
All sequences(16)
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Alleles
and
phenotypes
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All alleles(1) :
Targeted, knock-out(1)
| Homozygotes show occasional fibrin deposits in non-healing ulcerations and reduced neointima formation after arterial injury. They are susceptible to thrombosis after traumatic or inflammatory challenge and appear to be immunologically hyporesponsive displaying characteristics of functional anergy. |
Associated Human Diseases (1)
Alleles Annotated to Human Diseases (1)
|
|
Polymorphisms
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All PCR and RFLP(14) :
PCR(7)
RFLP(7)
SNPs within 2kb(54 from dbSNP Build 128)
|
Gene Ontology
(GO)
classifications
|
|
|
Expression
|
Literature Summary: (21 records)
Data Summary:
Assays (7)
Results (166)
Tissues (146)
Images (19)
Theiler Stages: 1,2,3,4,11,13,15,16,17,18,19,20,21,22,23,24,25,26,28
| |
Assay Type |
Assays |
|
Results |
| |
RT-PCR |
3 |
|
21 |
| |
RNA in situ |
3 |
|
134 |
| |
Northern blot |
1 |
|
11 |
cDNA source data(10)
External Resources:
Allen Brain Atlas
GEO
|
Molecular
reagents
|
All nucleic(21)
cDNA(11)
Primer pair(8)
Other(2)
Microarray probesets(3)
|
Other database
links
|
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Protein
domains
|
| InterPro ID |
Description |
| IPR000001 |
Kringle |
| IPR000742 |
EGF-like, type 3 |
| IPR001254 |
Peptidase S1/S6, chymotrypsin/Hap |
| IPR001314 |
Peptidase S1A, chymotrypsin |
| IPR006210 |
EGF-like |
| IPR009003 |
Serine/cysteine peptidase, trypsin-like |
| IPR013032 |
EGF-like region, conserved site |
| IPR013111 |
EGF, extracellular |
| IPR013806 |
Kringle-like fold |
| IPR018056 |
Kringle, conserved site |
| IPR018059 |
Kringle, subgroup |
| IPR018114 |
Peptidase S1/S6, chymotrypsin/Hap, active site |
Graphical View
of Protein Domain Structure
|
|
References
|
(Earliest)
J:7809
Belin D et al.,
"Cloning, nucleotide sequencing and expression of cDNAs encoding mouse urokinase-type plasminogen activator."
Eur J Biochem 1985 Apr 15;148(2):225-32
(Latest)
J:149628
Shanmukhappa K et al.,
"Plasmin-mediated proteolysis is required for hepatocyte growth factor activation during liver repair."
J Biol Chem 2009 May 8;284(19):12917-23
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All references(161)
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Other
accession IDs
|
MGD-MRK-13347
|
