Symbol
Name
ID
|
|
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Synonyms
|
5830406C15Rik, PKC[e], Pkce, PKCepsilon
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Genetic Map
|
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Chromosome 17
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Syntenic
|
|
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Mapping data(
2)
|
|
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Sequence Map
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Mammalian
homology
|
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Sequences
|
All sequences(20)
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Alleles
and
phenotypes
|
All alleles(6) :
Targeted, knock-out(3)
Targeted, other(1)
Gene trapped(2)
| Homozygotes for a targeted null mutation exhibit reduced ethanol self-administration and are more sensitive to the acute behavioral effects of ethanol and other drugs that activate GABA(A) receptors. Mutants show reduced anxiety and stress hormones. |
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Polymorphisms
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SNPs within 2kb(2139 from dbSNP Build 128)
|
Gene Ontology
(GO)
classifications
|
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|
Expression
|
Literature Summary: (13 records)
Data Summary:
Assays (3)
Results (18)
Tissues (10)
Images (2)
Theiler Stages: 21,22,23,24,25,26,28
| |
Assay Type |
Assays |
|
Results |
| |
Western blot |
2 |
|
17 |
| |
RNA in situ |
1 |
|
1 |
cDNA source data(8)
External Resources:
Allen Brain Atlas
GENSAT
GEO
|
Molecular
reagents
|
All nucleic(12)
cDNA(11)
Primer pair(1)
Antibodies(2)
Microarray probesets(3)
|
Other database
links
|
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Protein
domains
|
| InterPro ID |
Description |
| IPR000008 |
C2 calcium-dependent membrane targeting |
| IPR000719 |
Protein kinase, catalytic domain |
| IPR000961 |
AGC-kinase, C-terminal |
| IPR002219 |
Protein kinase C-like, phorbol ester/diacylglycerol binding |
| IPR002290 |
Serine/threonine-protein kinase domain |
| IPR008271 |
Serine/threonine-protein kinase, active site |
| IPR014376 |
Protein kinase C, delta/epsilon/eta/theta types |
| IPR015745 |
Protein kinase C |
| IPR017441 |
Protein kinase, ATP binding site |
| IPR017442 |
Serine/threonine-protein kinase-like domain |
| IPR017892 |
Protein kinase, C-terminal |
| IPR018029 |
C2 membrane targeting protein |
| IPR020454 |
Diacylglycerol/phorbol-ester binding |
Graphical View
of Protein Domain Structure
|
|
References
|
(Earliest)
J:10128
Wada H et al.,
"Cell type-specific expression of the genes for the protein kinase C family: down regulation of mRNAs for PKC alpha and nPKC epsilon upon in vitro differentiation of a mouse neuroblastoma cell line neuro 2a."
Biochem Biophys Res Commun 1989 Nov 30;165(1):533-8
(Latest)
J:151115
Lesscher HM et al.,
"Amygdala protein kinase C epsilon controls alcohol consumption."
Genes Brain Behav 2009 Jul;8(5):493-9
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All references(91)
|
Other
accession IDs
|
MGD-MRK-13331, MGI:1914847, MGI:2147156
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