Symbol
Name
ID
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Synonyms
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Pkcc, PKCgamma
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Genetic Map
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Sequence Map
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Mammalian
homology
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Sequences
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All sequences(20)
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Alleles
and
phenotypes
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All alleles(3) :
Targeted, knock-out(1)
Targeted, other(1)
Gene trapped(1)
| Depending upon genetic background, homozygous null mice show mild deficits in spatial learning and contextual conditioning. Genotype-dependent reductions in sensitivity to the effects of ethanol on righting reflex and hypothermia, in neuropathic pain after injury, and in anxiety are also evident. |
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Polymorphisms
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RFLP(7)
SNPs within 2kb(65 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
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Expression
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Literature Summary: (24 records)
Data Summary:
Assays (3)
Results (101)
Tissues (52)
Images (3)
Theiler Stages: 21,22,23,24,25,26,28
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Assay Type |
Assays |
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Results |
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Western blot |
1 |
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9 |
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RT-PCR |
2 |
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92 |
cDNA source data(21)
External Resources:
Allen Brain Atlas
GENSAT
GEO
ArrayExpress
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Molecular
reagents
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All nucleic(30)
Genomic(3)
cDNA(24)
Primer pair(2)
Other(1)
Antibodies(1)
Microarray probesets(1)
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Other database
links
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Protein
domains
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| InterPro ID |
Description |
| IPR000008 |
C2 calcium-dependent membrane targeting |
| IPR000719 |
Protein kinase, catalytic domain |
| IPR000961 |
AGC-kinase, C-terminal |
| IPR002219 |
Protein kinase C-like, phorbol ester/diacylglycerol binding |
| IPR002290 |
Serine/threonine-protein kinase domain |
| IPR008271 |
Serine/threonine-protein kinase, active site |
| IPR008973 |
C2 calcium/lipid-binding domain, CaLB |
| IPR011009 |
Protein kinase-like domain |
| IPR014375 |
Protein kinase C, alpha/beta/gamma types |
| IPR015745 |
Protein kinase C |
| IPR017441 |
Protein kinase, ATP binding site |
| IPR017442 |
Serine/threonine-protein kinase-like domain |
| IPR017892 |
Protein kinase, C-terminal |
| IPR018029 |
C2 membrane targeting protein |
| IPR020454 |
Diacylglycerol/phorbol-ester binding |
| IPR020477 |
C2 region |
Graphical View
of Protein Domain Structure
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References
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(Earliest)
J:12309
Yang-Feng TL et al.,
"Protein kinase C genes in the mouse: Pkca maps to MMU 11 and Pkcc to MMU7."
Cytogenet Cell Genet 1987;46():723
(Latest)
J:152410
Komai T et al.,
"Expression of the mouse PR domain protein Prdm8 in the developing central nervous system."
Gene Expr Patterns 2009 Oct;9(7):503-14
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All references(102)
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Other
accession IDs
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MGD-MRK-13329
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Analysis Tools
MGI BioMart
