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Prkcb Gene Detail
 Symbol
Name
ID
Prkcb
protein kinase C, beta
MGI:97596

Nomenclature History
Synonyms A130082F03Rik, PKC-Beta, Pkcb, Prkcb1, Prkcb2
Genetic Map
Chromosome 7
60.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 11)

Sequence Map
Chr7:129432265-129777916 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; cattle; dog, domestic; rabbit, European; rat; sheep    (Mammalian Orthology)
Comparative Map (Mouse/Human Prkcb ± 2 cM)
Protein SuperFamily: protein kinase C, alpha/beta/gamma types
TreeFam: TF102004
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000016521 VEGA Gene Model | MGI Sequence Detail 345652 C57BL/6J ± Kb
transcript NM_008855 RefSeq | MGI Sequence Detail 8830 C57BL/6
polypeptide P68404 UniProt | EBI | MGI Sequence Detail 673 Not Applicable
For the selected sequences
All sequences(23)
Alleles
and
phenotypes 		All alleles(1) : Targeted, other(1)
Polymorphisms RFLP(3) SNPs within 2kb(2013 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process calcium ion transport, cellular calcium ion homeostasis...
Component cytoplasm, membrane...
Function ATP binding, calcium channel regulator activity...
External Resources: FuncBase
Expression Literature Summary: (18 records)
Data Summary: Assays (2)    Results (17)    Tissues (9)    Images (1)
Theiler Stages: 21,22,23,24,25,26,28
  Assay Type Assays   Results
      Western blot 2   17
cDNA source data(79)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(84) Genomic(1) cDNA(82) Other(1) Antibodies(2)
Microarray probesets(3)
Other database
links
EC 2.7.11.13
Ensembl Gene Model ENSMUSG00000052889
DoTS DT.532374, DT.97356798
Consensus CDS Project CCDS21815.1
UniGene 207496
DFCI TC1579462, TC1582051, TC1625960
NIA Mouse Gene Index U008730
Entrez Gene 18751
VEGA Gene Model OTTMUSG00000016521
International Mouse Knockout Project Status Prkcb
Protein
domains
InterPro ID Description
IPR000008 C2 calcium-dependent membrane targeting
IPR000719 Protein kinase, catalytic domain
IPR000961 AGC-kinase, C-terminal
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
IPR002290 Serine/threonine-protein kinase domain
IPR008271 Serine/threonine-protein kinase, active site
IPR008973 C2 calcium/lipid-binding domain, CaLB
IPR011009 Protein kinase-like domain
IPR014375 Protein kinase C, alpha/beta/gamma types
IPR015745 Protein kinase C
IPR017441 Protein kinase, ATP binding site
IPR017442 Serine/threonine-protein kinase-like domain
IPR017892 Protein kinase, C-terminal
IPR018029 C2 membrane targeting protein
IPR020454 Diacylglycerol/phorbol-ester binding
IPR020477 C2 region
Graphical View of Protein Domain Structure
References
(Earliest) J:10128 Wada H et al., "Cell type-specific expression of the genes for the protein kinase C family: down regulation of mRNAs for PKC alpha and nPKC epsilon upon in vitro differentiation of a mouse neuroblastoma cell line neuro 2a." Biochem Biophys Res Commun 1989 Nov 30;165(1):533-8
(Latest) J:147225 Harja E et al., "Mice deficient in PKCbeta and apolipoprotein E display decreased atherosclerosis." FASEB J 2009 Apr;23(4):1081-91
All references(83)
Other
accession IDs 		MGD-MRK-13328, MGI:2442598
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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