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Pcp2 Gene Detail
 Symbol
Name
ID
Pcp2
Purkinje cell protein 2 (L7)
MGI:97508


Nomenclature History
Synonyms L7, Pcp-2
Genetic Map
Chromosome 8
1.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 9)

Sequence Map
Chr8:3623371-3625545 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Pcp2 ± 2 cM)
TreeFam: TF338628
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000032848 VEGA Gene Model | MGI Sequence Detail 2175 C57BL/6J ± Kb
transcript NM_008790 RefSeq | MGI Sequence Detail 513 -
polypeptide P12660 UniProt | EBI | MGI Sequence Detail 120 Not Applicable
For the selected sequences
All sequences(33)
Alleles
and
phenotypes
All alleles(7) : Targeted, knock-out(2) Targeted, other(2) Gene trapped(3)
Mice homozygous for a null mutation do not exhibit any detectable abnormalities.
Polymorphisms RFLP(3) SNPs within 2kb(23 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(3)
Process signal transduction
Function GTPase activator activity, guanyl-nucleotide exchange factor activity...
External Resources: MouseFunc
Expression Literature Summary: (6 records)
Data Summary: Assays (4)    Results (25)    Tissues (4)
Theiler Stages: 23,26,28
  Assay Type Assays   Results
      RT-PCR 3   24
      RNA in situ 1   1
cDNA source data(8)
External Resources: Allen Brain Atlas  GENSAT  GEO 
Molecular
reagents
All nucleic(14) Genomic(2) cDNA(9) Primer pair(3)
Microarray probesets(6)
Other database
links
Ensembl Gene Model ENSMUSG00000004630
DoTS DT.101360797, DT.101360798, DT.40167174, DT.532713, DT.99848833, DT.99862194
NIA Mouse Gene Index U029538
Entrez Gene 18545
VEGA Gene Model OTTMUSG00000032848
International Mouse Knockout Project Status Pcp2
Protein
domains
InterPro ID Description
IPR003109 GoLoco motif
Graphical View of Protein Domain Structure
References
(Earliest) J:9499 Nordquist DT et al., "cDNA cloning and characterization of three genes uniquely expressed in cerebellum by Purkinje neurons." J Neurosci 1988 Dec;8(12):4780-9
(Latest) J:146989 Iscru E et al., "Sensorimotor enhancement in mouse mutants lacking the Purkinje cell-specific Gi/o modulator, Pcp2(L7)." Mol Cell Neurosci 2009 Jan;40(1):62-75
All references(28)
Other
accession IDs
MGD-MRK-13183, MGD-MRK-13186

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/20/2009
MGI_4.31
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The Jackson Laboratory