Symbol
Name
ID
|
|
|
STS
|
D4Nds13
|
|
Synonyms
|
Anf, ANP, atrial natriuretic peptide, natriuretic peptide precursor A, Pnd
|
|
Genetic Map
|
|
|
Sequence Map
|
|
Mammalian
homology
|
|
|
Sequences
|
All sequences(15)
|
Alleles
and
phenotypes
|
All alleles(3) :
Targeted, knock-out(1)
Gene trapped(2)
| Homozygotes are chronically hypertensive partly due to changes in peripheral resistance and increased central AT1-receptor activation, and show salt-sensitive hypertension and abnormal pulmonary vascular remodeling with increased ventricular mass and muscularization of peripheral pulmonary vessels. |
|
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Polymorphisms
|
All PCR and RFLP(23) :
PCR(6)
RFLP(17)
SNPs within 2kb(27 from dbSNP Build 128)
|
Gene Ontology
(GO)
classifications
|
|
|
Expression
|
Literature Summary: (132 records)
Data Summary:
Assays (24)
Results (120)
Tissues (60)
Images (32)
Theiler Stages: 11,12,13,14,15,16,17,18,19,20,21,22,23,24,26,28
| |
Assay Type |
Assays |
|
Results |
| |
RT-PCR |
7 |
|
26 |
| |
RNA in situ |
10 |
|
63 |
| |
Northern blot |
6 |
|
29 |
| |
RNase protection |
1 |
|
2 |
cDNA source data(96)
External Resources:
GENSAT
GEO
|
Molecular
reagents
|
All nucleic(133)
Genomic(9)
cDNA(102)
Primer pair(10)
Other(12)
Microarray probesets(2)
|
Other database
links
|
|
Protein
domains
|
| InterPro ID |
Description |
| IPR000663 |
Natriuretic peptide |
| IPR002407 |
Natriuretic peptide, atrial type |
Graphical View
of Protein Domain Structure
|
|
References
|
(Earliest)
J:7667
Seidman CE et al.,
"Nucleotide sequences of the human and mouse atrial natriuretic factor genes."
Science 1984 Dec 7;226(4679):1206-9
(Latest)
J:153091
Berman SD et al.,
"Mutation of p107 exacerbates the consequences of Rb loss in embryonic tissues and causes cardiac and blood vessel defects."
Proc Natl Acad Sci U S A 2009 Sep 1;106(35):14932-6
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All references(230)
|
Other
accession IDs
|
MGD-MRK-12921, MGD-MRK-1319, MGD-MRK-13536
|
