Symbol
Name
ID
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Synonyms
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LNGFR, p75, p75 neurotrophin receptor, p75NGFR, p75NTR, Tnfrsf16
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Genetic Map
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Sequence Map
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Mammalian
homology
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Sequences
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All sequences(19)
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Alleles
and
phenotypes
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All alleles(12) :
Targeted, knock-out(2)
Targeted, other(1)
Gene trapped(9)
| Homozygotes for targeted mutations exhibit increased perinatal lethality, skin abnormalities, growth retardation, reduced sensory nerve innervation, elevated pain threshold, ataxia, reduced sciatic nerve diameter, and blood vessel abnormalities. |
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Polymorphisms
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All PCR and RFLP(5) :
PCR(2)
RFLP(3)
SNPs within 2kb(121 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
|
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Expression
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Literature Summary: (150 records)
Data Summary:
Assays (22)
Results (247)
Tissues (153)
Images (45)
Theiler Stages: 14,15,16,17,18,19,20,21,22,23,24,25,26,28
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Assay Type |
Assays |
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Results |
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Northern blot |
2 |
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6 |
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RT-PCR |
7 |
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79 |
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RNA in situ |
4 |
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108 |
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Immunohistochemistry |
7 |
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45 |
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Western blot |
2 |
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9 |
cDNA source data(27)
External Resources:
Allen Brain Atlas
GENSAT
GEO
|
Molecular
reagents
|
All nucleic(48)
Genomic(3)
cDNA(36)
Primer pair(6)
Other(3)
Antibodies(6)
Microarray probesets(2)
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Other database
links
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Protein
domains
|
Graphical View
of Protein Domain Structure
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References
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(Earliest)
J:14649
Sutter A et al.,
"Nerve growth factor receptors. Characterization of two distinct classes of binding sites on chick embryo sensory ganglia cells."
J Biol Chem 1979 Jul 10;254(13):5972-82
(Latest)
J:153654
Holm MM et al.,
"Mature BDNF, but not proBDNF, reduces excitability of fast-spiking interneurons in mouse dentate gyrus."
J Neurosci 2009 Oct 7;29(40):12412-8
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All references(320)
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Other
accession IDs
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MGD-MRK-12842
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