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Nfkb1 Gene Detail
 Symbol
Name
ID
Nfkb1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105
MGI:97312

Nomenclature History
Synonyms NF kappaB1, NF-kappaB, nuclear factor kappaB p50, p50, p50 subunit of NF kappaB, p50/p105
Genetic Map
Chromosome 3
68.9 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 13)

Sequence Map
Chr3:135247619-135354511 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rabbit, European; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Nfkb1 ± 2 cM)
Protein SuperFamily: transcription factor NF-kappa-B2
TreeFam: TF325632
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000016668 VEGA Gene Model | MGI Sequence Detail 106893 C57BL/6J ± Kb
transcript NM_008689 RefSeq | MGI Sequence Detail 4128 C57BL/6
polypeptide P25799 UniProt | EBI | MGI Sequence Detail 971 Not Applicable
For the selected sequences
All sequences(46)
Alleles
and
phenotypes 		All alleles(58) : Targeted, knock-out(2) Targeted, other(3) Gene trapped(53)
Homozygous null mice have a decreased survivor rate, abnormal T cell development and decreased number of peripheral T cells, abnormal humoral responses with decreased immunoglobulin class switching, exhibit mild organ inflammation, and are susceptible to both bacterial infections and hearing loss.
Polymorphisms RFLP(1) SNPs within 2kb(738 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process apoptosis, lymph node development...
Component cytoplasm, cytosol...
Function DNA binding, protein binding...
External Resources: FuncBase
Expression Literature Summary: (11 records)
Data Summary: Assays (5)    Results (183)    Tissues (169)    Images (18)
Theiler Stages: 2,3,4,5,16,18,20,21,22,23,25,28
  Assay Type Assays   Results
      RT-PCR 2   57
      RNA in situ 3   126
cDNA source data(115)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(120) cDNA(116) Primer pair(4)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000028163
DoTS DT.101143716, DT.101326875, DT.87055129, DT.91419108, DT.91427614, DT.91573435, DT.94183786, DT.94250067
Consensus CDS Project CCDS17858.1
UniGene 256765
PDB 1BFS, 1IKN, 1LE5, 1LE9, 1LEI, 1NFK, 1OOA, 1U36, 1U3J, 1U3Y, 1U3Z, 1U41, 1U42, 1VKX, 2I9T, 2V2T
DFCI TC1575839, TC1589850, TC1604939, TC1610242, TC1660191
NIA Mouse Gene Index U024684
Entrez Gene 18033
VEGA Gene Model OTTMUSG00000016668
International Mouse Knockout Project Status Nfkb1
Protein
domains
InterPro ID Description
IPR000451 NF-kappa-B/Rel/dorsal
IPR000488 Death
IPR002110 Ankyrin repeat
IPR002909 Cell surface receptor IPT/TIG
IPR008967 p53-like transcription factor, DNA-binding
IPR011029 DEATH-like
IPR011539 Rel homology
IPR013783 Immunoglobulin-like fold
IPR014756 Immunoglobulin E-set
IPR020683 Ankyrin repeat-containing domain
Graphical View of Protein Domain Structure
References
(Earliest) J:13626 Ferguson JM et al., "Stumpy" Mouse News Lett 1973;49():23
(Latest) J:156177 Ruan Q et al., "Development of Foxp3(+) regulatory t cells is driven by the c-Rel enhanceosome." Immunity 2009 Dec 18;31(6):932-40
All references(307)
Other
accession IDs 		MGD-MRK-12829
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
Web browser compatibility 		The Jackson Laboratory