About   Help   FAQ
Neu1 Gene Detail
 Symbol
Name
ID
Neu1
neuraminidase 1
MGI:97305


Nomenclature History
Synonyms Aglp, Apl, Bat-7, Bat7, G9, lysosomal sialidase, Map-2, Neu-1, sialidase 1
Genetic Map
Chromosome 17
18.93 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 20)

Sequence Map
Chr17:35068324-35072266 bp, + strand
(From NCBI annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Neu1 ± 2 cM)
TreeFam: TF331063
Sequences
Representative Sequences Length Strain/Species Flank
genomic 18010 NCBI Gene Model | MGI Sequence Detail 3943 C57BL/6J ± Kb
transcript NM_010893 RefSeq | MGI Sequence Detail 3850 C57BL/6
polypeptide O35657 UniProt | EBI | MGI Sequence Detail 409 Not Applicable
For the selected sequences
All sequences(38)
Alleles
and
phenotypes
All alleles(4) : Targeted, other(1) Other(3)
Associated Human Diseases (1)   Alleles Annotated to Human Diseases (2)  
Polymorphisms SNPs within 2kb(39 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(9)
Process metabolic process
Component cytoplasmic vesicle, lysosome...
Function exo-alpha-sialidase activity, hydrolase activity...
External Resources: MouseFunc
Expression Literature Summary: (7 records)
Data Summary: Assays (1)    Results (7)    Tissues (5)
Theiler Stages: 20,22,24,26,28
  Assay Type Assays   Results
      RT-PCR 1   7
cDNA source data(168)
External Resources: Allen Brain Atlas  GEO 
Molecular
reagents
All nucleic(174) Genomic(3) cDNA(169) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
EC 3.2.1.18
Ensembl Gene Model ENSMUSG00000007038
DoTS DT.101128296, DT.111069065, DT.494582
UniGene 8856
DFCI TC1572949, TC1639805, TC1642176, TC1677449, TC1778992
NIA Mouse Gene Index U017876
Entrez Gene 18010
International Mouse Knockout Project Status Neu1
Protein
domains
InterPro ID Description
IPR011040 Neuraminidase
Graphical View of Protein Domain Structure
References
(Earliest) J:4457 Lalley PA et al., "Lysosomal Acid Phosphatase Deficiency: Liver Specific Variant in the Mouse." Genetics 1977 Oct;87(2):305-317
(Latest) J:153180 Shiozaki K et al., "Developmental change of sialidase neu4 expression in murine brain and its involvement in the regulation of neuronal cell differentiation." J Biol Chem 2009 Aug 7;284(32):21157-64
All references(50)
Other
accession IDs
MGD-MRK-1182, MGD-MRK-12114, MGD-MRK-12819, MGD-MRK-12820, MGD-MRK-1358, MGD-MRK-1504, MGD-MRK-1512, MGI:2146738, MGI:2146740, MGI:88131

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/20/2009
MGI_4.31
Web browser compatibility
The Jackson Laboratory