Symbol
Name
ID
|
|
|
Synonyms
|
macrophage elastase, Mmel, MMP12
|
|
Genetic Map
|
|
|
Sequence Map
|
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Mammalian
homology
|
|
|
Sequences
|
All sequences(69)
|
Alleles
and
phenotypes
|
All alleles(1) :
Targeted, knock-out(1)
|
|
Polymorphisms
|
RFLP(1)
SNPs within 2kb(72 from dbSNP Build 128)
|
Gene Ontology
(GO)
classifications
|
|
|
Expression
|
Literature Summary: (3 records)
Data Summary:
Assays (1)
Results (5)
Tissues (3)
Theiler Stages: 19,28
| |
Assay Type |
Assays |
|
Results |
| |
RT-PCR |
1 |
|
5 |
cDNA source data(56)
External Resources:
Allen Brain Atlas
GEO
|
Molecular
reagents
|
All nucleic(61)
Genomic(4)
cDNA(56)
Primer pair(1)
Microarray probesets(2)
|
Other database
links
|
| EC |
3.4.24.65 |
| Ensembl Gene Model |
ENSMUSG00000049723 |
| DoTS |
DT.101135750, DT.101164333, DT.101312843, DT.101323612, DT.101346217, DT.101407043, DT.101407055, DT.101407068, DT.101407084, DT.97402107 |
| UniGene |
2055 |
| DFCI |
TC1573624, TC1596006 |
| NIA Mouse Gene Index |
U010022 |
| Entrez Gene |
17381 |
| VEGA Gene Model |
OTTMUSG00000027381 |
| International Mouse Knockout Project Status |
Mmp12 |
|
Protein
domains
|
| InterPro ID |
Description |
| IPR000585 |
Hemopexin/matrixin |
| IPR001818 |
Peptidase M10A/M12B, matrixin/adamalysin |
| IPR002477 |
Peptidoglycan binding-like |
| IPR006025 |
Peptidase M, neutral zinc metallopeptidases, zinc-binding site |
| IPR006026 |
Peptidase, metallopeptidases |
| IPR016293 |
Peptidase M10A, matrix metallopeotidase |
| IPR018486 |
Hemopexin/matrixin, conserved site |
| IPR018487 |
Hemopexin/matrixin, repeat |
Graphical View
of Protein Domain Structure
|
|
References
|
(Earliest)
J:11522
Denis M et al.,
"Tumor necrosis factor plays an essential role in determining hypersensitivity pneumonitis in a mouse model."
Am J Respir Cell Mol Biol 1991 Nov;5(5):477-83
(Latest)
J:150964
Houghton AM et al.,
"Macrophage elastase kills bacteria within murine macrophages."
Nature 2009 Jul 30;460(7255):637-41
|
All references(51)
|
Other
accession IDs
|
MGD-MRK-12275, MGI:2143275
|
