Symbol
Name
ID
|
|
|
Synonyms
|
Lef-1, lymphoid enhancer factor 1
|
|
Genetic Map
|
|
|
Sequence Map
|
|
Mammalian
homology
|
|
|
Sequences
|
All sequences(34)
|
Alleles
and
phenotypes
|
All alleles(5) :
Targeted, knock-out(1)
Targeted, other(1)
Gene trapped(3)
| Homozygotes for targeted null mutations lack teeth, mammary glands, hair, dentate gyrus granule cells, and submucosal glands, and die postnatally. Mutants' pro-B cells exhibit defects in proliferation and survival. |
|
|
Polymorphisms
|
RFLP(1)
SNPs within 2kb(425 from dbSNP Build 128)
|
Gene Ontology
(GO)
classifications
|
|
|
Expression
|
Literature Summary: (140 records)
Data Summary:
Assays (26)
Results (276)
Tissues (190)
Images (95)
Theiler Stages: 1,2,3,4,5,11,12,13,17,18,19,20,21,22,23,24,25,26,28
| |
Assay Type |
Assays |
|
Results |
| |
RT-PCR |
6 |
|
44 |
| |
RNA in situ |
18 |
|
214 |
| |
Immunohistochemistry |
2 |
|
18 |
cDNA source data(63)
External Resources:
Allen Brain Atlas
GENSAT
GEO
|
Molecular
reagents
|
All nucleic(81)
Genomic(1)
cDNA(67)
Primer pair(7)
Other(6)
Antibodies(2)
Microarray probesets(2)
|
Other database
links
|
| Ensembl Gene Model |
ENSMUSG00000027985 |
| DoTS |
DT.101138159, DT.101307293, DT.101375180, DT.101721252, DT.533548, DT.94342537 |
| UniGene |
255219 |
| PDB |
2LEF |
| DFCI |
TC1578581, TC1586991, TC1587963, TC1631022, TC1704377, TC1762627 |
| Entrez Gene |
16842 |
| VEGA Gene Model |
OTTMUSG00000020276 |
| International Mouse Knockout Project Status |
Lef1 |
|
Protein
domains
|
| InterPro ID |
Description |
| IPR000910 |
High mobility group, HMG1/HMG2 |
| IPR009071 |
High mobility group, superfamily |
| IPR013558 |
CTNNB1 binding, N-teminal |
Graphical View
of Protein Domain Structure
|
|
References
|
(Earliest)
J:10393
Mattei MG et al.,
"Chromosomal localization of the three members of the jun proto-oncogene family in mouse and man."
Oncogene 1990 Jan;5(1):151-6
(Latest)
J:153566
Fujimura N et al.,
"Spatial and temporal regulation of Wnt/beta-catenin signaling is essential for development of the retinal pigment epithelium."
Dev Biol 2009 Oct 1;334(1):31-45
|
All references(180)
|
Other
accession IDs
|
MGD-MRK-11782, MGD-MRK-11783, MGI:2139722
|
|
