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Lck Gene Detail
 Symbol
Name
ID
Lck
lymphocyte protein tyrosine kinase
MGI:96756

Nomenclature History
STS D4Nds20
Synonyms Hck-3, p56lck
Genetic Map
Chromosome 4
59.0 cM, cytoband distal
Detailed Genetic Map ± 1 cM
 
Mapping data( 60)

Sequence Map
Chr4:129225593-129250885 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; cattle; dog, domestic; rat; sheep    (Mammalian Orthology)
Comparative Map (Mouse/Human Lck ± 2 cM)
Protein SuperFamily: tyrosine-protein kinase, proto-oncogene SRC type
TreeFam: TF351634
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000009667 VEGA Gene Model | MGI Sequence Detail 25293 C57BL/6J ± Kb
transcript NM_010693 RefSeq | MGI Sequence Detail 2171 -
polypeptide P06240 UniProt | EBI | MGI Sequence Detail 509 Not Applicable
For the selected sequences
All sequences(31)
Alleles
and
phenotypes 		All alleles(17) : Targeted, knock-out(2) Targeted, other(2) Gene trapped(12) Chemically induced(1)
Mice homozygous for mutations of this gene exhibit thymic atrophy with reduced numbers of peripheral T cells. Null mutants have few double positive and no mature single positive (SP) thymocytes. A hypomorph has decreased expression of CD3epsilon chain on SP thymocytes, whose numbers are reduced.
Polymorphisms All PCR and RFLP(18) : PCR(4) RFLP(14) SNPs within 2kb(135 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process B cell receptor signaling pathway, cell surface receptor linked signal transduction...
Component cytoplasm, membrane...
Function ATP binding, kinase activity...
External Resources: FuncBase
Expression Literature Summary: (1 records)
cDNA source data(24)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(41) Genomic(8) cDNA(28) Primer pair(4) Other(1)
Microarray probesets(3)
Other database
links
EC 2.7.10.2
Ensembl Gene Model ENSMUSG00000000409
Consensus CDS Project CCDS18697.1
Entrez Gene 16818
VEGA Gene Model OTTMUSG00000009667
International Mouse Knockout Project Status Lck
Protein
domains
InterPro ID Description
IPR000719 Protein kinase, catalytic domain
IPR000980 SH2 motif
IPR001245 Tyrosine-protein kinase, catalytic domain
IPR001452 Src homology-3 domain
IPR008266 Tyrosine-protein kinase, active site
IPR011009 Protein kinase-like domain
IPR017441 Protein kinase, ATP binding site
IPR020473 Src homology-3, region
IPR020635 Tyrosine-protein kinase, subgroup, catalytic domain
IPR020685 Tyrosine-protein kinase
IPR020749 Tyrosine-protein kinase, non-receptor Lck
Graphical View of Protein Domain Structure
References
(Earliest) J:8130 Marth JD et al., "A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA." Cell 1985 Dec;43(2 Pt 1):393-404
(Latest) J:152472 Kim JK et al., "Impact of the TCR signal on regulatory T cell homeostasis, function, and trafficking." PLoS One 2009;4(8):e6580
All references(160)
Other
accession IDs 		MGD-MRK-10669, MGD-MRK-11758
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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