Symbol
Name
ID
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Synonyms
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Flk-1, Flk1, vascular endothelial growth factor receptor- 2, VEGF receptor-2, VEGFR-2, VEGFR2
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Genetic Map
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Sequence Map
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Mammalian
homology
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Sequences
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All sequences(26)
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Alleles
and
phenotypes
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All alleles(10) :
Targeted, knock-out(1)
Targeted, other(9)
| Homozygotes for targeted null mutations exhibit defects in hematopoietic and endothelial cells, impaired liver morphogenesis, and die by embryonic day 9.5. |
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Polymorphisms
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RFLP(1)
SNPs within 2kb(185 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
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Expression
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Literature Summary: (273 records)
Data Summary:
Assays (61)
Results (493)
Tissues (249)
Images (146)
Theiler Stages: 8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,26,28
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Assay Type |
Assays |
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Results |
| |
Western blot |
2 |
|
3 |
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RT-PCR |
22 |
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191 |
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In situ reporter (knock in) |
3 |
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27 |
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RNA in situ |
20 |
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178 |
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Immunohistochemistry |
9 |
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48 |
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Northern blot |
4 |
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45 |
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RNase protection |
1 |
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1 |
cDNA source data(99)
External Resources:
Allen Brain Atlas
GENSAT
GEO
|
Molecular
reagents
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All nucleic(141)
Genomic(8)
cDNA(107)
Primer pair(14)
Other(12)
Antibodies(9)
Microarray probesets(2)
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Other database
links
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Protein
domains
|
| InterPro ID |
Description |
| IPR000719 |
Protein kinase, catalytic domain |
| IPR001245 |
Tyrosine-protein kinase, catalytic domain |
| IPR001824 |
Tyrosine-protein kinase, receptor class III, conserved site |
| IPR003598 |
Immunoglobulin subtype 2 |
| IPR003599 |
Immunoglobulin subtype |
| IPR007110 |
Immunoglobulin-like |
| IPR008266 |
Tyrosine-protein kinase, active site |
| IPR009134 |
Tyrosine-protein kinase, vascular endothelial growth factor receptor (VEGFR), N-terminal |
| IPR009136 |
Tyrosine-protein kinase, vascular endothelial growth factor receptor 2 (VEGFR2) |
| IPR011009 |
Protein kinase-like domain |
| IPR013098 |
Immunoglobulin I-set |
| IPR013106 |
Immunoglobulin V-set |
| IPR013151 |
Immunoglobulin |
| IPR013783 |
Immunoglobulin-like fold |
| IPR017441 |
Protein kinase, ATP binding site |
| IPR020635 |
Tyrosine-protein kinase, subgroup, catalytic domain |
Graphical View
of Protein Domain Structure
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References
|
(Earliest)
J:1615
Matthews W et al.,
"A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit."
Proc Natl Acad Sci U S A 1991 Oct 15;88(20):9026-30
(Latest)
J:154336
Albuquerque RJ et al.,
"Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth."
Nat Med 2009 Sep;15(9):1023-30
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All references(352)
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Other
accession IDs
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MGD-MRK-11605, MGD-MRK-11606, MGD-MRK-9826, MGD-MRK-9828, MGI:95555
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