Kit MGI Mouse Gene Detail - MGI:96677

Kit Gene Detail

Symbol
Name
ID

Kit
kit oncogene
MGI:96677

Synonyms

belly-spot, c-KIT, CD117, Dominant white spotting, Gsfsco1, Gsfsco5, Gsfsow3, SCO1, SCO5, SOW3, Steel Factor Receptor, Tr-kit

Genetic Map

Chromosome 5
42.0 cM
Detailed Genetic Map ± 1 cM

Mapping data( 117)

Sequence Map

Chr5:75970941-76052747 bp, + strand

(From VEGA annotation of NCBI Build 37)

VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian
homology

human; cat, domestic; chimpanzee; cattle; dog, domestic; pig, domestic; rat; sheep (Mammalian Orthology)

Comparative Map (Mouse/Human Kit ± 2 cM)

Protein SuperFamily: tyrosine-protein kinase, CSF-1/PDGF receptor type

TreeFam: TF325768

Sequences

All sequences(41)

Alleles
and
phenotypes

All alleles(128) : Targeted, other(12) Gene trapped(31) Spontaneous(66) Chemically induced(17) Radiation induced(2)

Mutations at this locus affect migration of embryonic stem cell populations, resulting in mild to severe impairments in hemopoiesis, and pigmentation. Some alleles are homozygous lethal, sterile, or result in the formation of gastrointestinal tumors.

Associated Human Diseases (2) Alleles Annotated to Human Diseases (4) Phenotype Images (9)

Polymorphisms

All PCR and RFLP(28) : PCR(3) RFLP(25) SNPs within 2kb(625 from dbSNP Build 128)

Gene Ontology
(GO)
classifications

All GO classifications(47)
Process	cell differentiation, chemotaxis...
Component	cell surface, external side of plasma membrane...
Function	ATP binding, kinase activity...
External Resources: MouseFunc

Expression

Literature Summary: (106 records)
Data Summary: Assays (38) Results (330) Tissues (139) Images (86)
Theiler Stages: 1,2,3,4,5,13,14,15,16,17,18,19,20,21,22,23,24,25,26,28

Assay Type	Assays	Results
RT-PCR	24	151
RNA in situ	7	113
Immunohistochemistry	5	56
Northern blot	1	6
RNase protection	1	4

cDNA source data(211)
External Resources: Allen Brain Atlas GENSAT GEO

Molecular
reagents

All nucleic(282) Genomic(39) cDNA(221) Primer pair(17) Other(5) Antibodies(2)
Microarray probesets(2)

Other database
links

EC	2.7.10.1
Ensembl Gene Model	ENSMUSG00000005672
DoTS	DT.101379609, DT.529646, DT.87057299
UniGene	247073
PDB	2O26
DFCI	TC1572427, TC1588664, TC1593379, TC1596961
NIA Mouse Gene Index	U005697
Entrez Gene	16590
VEGA Gene Model	OTTMUSG00000016671
International Mouse Knockout Project Status	Kit

Protein
domains

InterPro ID	Description
IPR000719	Protein kinase, catalytic domain
IPR001245	Tyrosine-protein kinase, catalytic domain
IPR001824	Tyrosine-protein kinase, receptor class III, conserved site
IPR003598	Immunoglobulin subtype 2
IPR003599	Immunoglobulin subtype
IPR007110	Immunoglobulin-like
IPR008266	Tyrosine-protein kinase, active site
IPR011009	Protein kinase-like domain
IPR013098	Immunoglobulin I-set
IPR013151	Immunoglobulin
IPR013783	Immunoglobulin-like fold
IPR016243	Tyrosine-protein kinase, CSF-1/PDGF receptor
IPR017441	Protein kinase, ATP binding site
IPR020635	Tyrosine-protein kinase, subgroup, catalytic domain

Graphical View of Protein Domain Structure

References

(Earliest) J:2447 Little CC et al., "The occurrence of a dominant spotting mutation in the house mouse" Proc Natl Acad Sci U S A 1937 Oct;23(10):535-537
(Latest) J:154206 Miyata M et al., "Thymic stromal lymphopoietin is a critical mediator of IL-13-driven allergic inflammation." Eur J Immunol 2009 Aug 5;39(11):3078-3083

All references(740)

Other
accession IDs

MGD-MRK-11588, MGD-MRK-14609, MGD-MRK-15420, MGD-MRK-1672, MGD-MRK-9743, MGI:3530304, MGI:3530312, MGI:3530319

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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