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Itgav Gene Detail
 Symbol
Name
ID
Itgav
integrin alpha V
MGI:96608

Nomenclature History
Synonyms 1110004F14Rik, 2610028E01Rik, alphav-integrin, CD51, D430040G12Rik, vitronectin receptor alpha polypeptide (VNRA)
Genetic Map
Chromosome 2
46.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 3)

Sequence Map
Chr2:83564554-83647073 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Itgav ± 2 cM)
Protein SuperFamily: integrin alpha, VLA protein type
TreeFam: TF105391
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000013360 VEGA Gene Model | MGI Sequence Detail 82520 C57BL/6J ± Kb
transcript NM_008402 RefSeq | MGI Sequence Detail 7054 C57BL/6
polypeptide P43406 UniProt | EBI | MGI Sequence Detail 1044 Not Applicable
For the selected sequences
All sequences(41)
Alleles
and
phenotypes 		All alleles(7) : Targeted, knock-out(2) Targeted, other(2) Gene trapped(3)
Homozygotes for a targeted null mutation exhibit placental defects, intracerebral and intestinal hemorrhages, and cleft palate, resulting in death occurring as early as midgestation and as late as shortly after birth.
Polymorphisms SNPs within 2kb(349 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process angiogenesis, apoptotic cell clearance...
Component external side of plasma membrane, integral to membrane...
Function calcium ion binding, protein binding...
External Resources: FuncBase
Expression Literature Summary: (18 records)
Data Summary: Assays (2)    Results (6)    Tissues (4)    Images (2)
Theiler Stages: 14,20
  Assay Type Assays   Results
      RT-PCR 1   4
      RNA in situ 1   2
cDNA source data(151)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(156) cDNA(153) Primer pair(1) Other(2)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000027087
DoTS DT.101132261, DT.101323055, DT.101712721, DT.492179, DT.91293780, DT.91378700, DT.91424478, DT.94384293
Consensus CDS Project CCDS16181.1
UniGene 227
DFCI TC1583434, TC1613040, TC1630599, TC1631200, TC1631622, TC1700428
NIA Mouse Gene Index U042324
Entrez Gene 16410
VEGA Gene Model OTTMUSG00000013360
International Mouse Knockout Project Status Itgav
Protein
domains
InterPro ID Description
IPR000413 Integrin alpha chain
IPR013513 Integrin alpha subunit, C-terminal cytoplasmic region
IPR013517 FG-GAP
IPR013519 Integrin alpha beta-propellor
IPR013649 Integrin alpha-2
IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site
Graphical View of Protein Domain Structure
References
(Earliest) J:10951 Moulder K et al., "The mouse vitronectin receptor is a T cell activation antigen." J Exp Med 1991 Feb 1;173(2):343-7
(Latest) J:153959 Conti FJ et al., "Talin 1 and 2 are required for myoblast fusion, sarcomere assembly and the maintenance of myotendinous junctions." Development 2009 Nov;136(21):3597-606
All references(49)
Other
accession IDs 		MGD-MRK-11487, MGI:1923548, MGI:1923608, MGI:2445000
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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