Symbol
Name
ID
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Synonyms
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Cd49e, Fnra
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Genetic Map
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Sequence Map
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Mammalian
homology
|
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Sequences
|
All sequences(47)
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Alleles
and
phenotypes
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All alleles(13) :
Targeted, knock-out(1)
Targeted, other(1)
Gene trapped(11)
| Homozygotes for a targeted null mutation exhibit severe defects in posterior trunk and yolk sac mesodermal structures, lack of epithelialization of somites, reduced numbers of Schwann cells, and lethality around embryonic day 10-11. |
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Polymorphisms
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RFLP(2)
SNPs within 2kb(84 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
|
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Expression
|
Literature Summary: (33 records)
Data Summary:
Assays (8)
Results (77)
Tissues (69)
Images (19)
Theiler Stages: 14,15,16,18,19,20,22,23,25,26,28
| |
Assay Type |
Assays |
|
Results |
| |
RT-PCR |
2 |
|
50 |
| |
RNA in situ |
2 |
|
8 |
| |
Immunohistochemistry |
4 |
|
19 |
cDNA source data(67)
External Resources:
Allen Brain Atlas
GEO
|
Molecular
reagents
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All nucleic(75)
Genomic(2)
cDNA(69)
Primer pair(3)
Other(1)
Antibodies(4)
Microarray probesets(3)
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Other database
links
|
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Protein
domains
|
| InterPro ID |
Description |
| IPR000413 |
Integrin alpha chain |
| IPR013513 |
Integrin alpha chain, C-terminal, cytoplasmic region |
| IPR013517 |
FG-GAP |
| IPR013519 |
Integrin alpha beta-propellor |
| IPR013649 |
Integrin alpha-2 |
| IPR018184 |
Integrin alpha chain, C-terminal cytoplasmic region, conserved site |
Graphical View
of Protein Domain Structure
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References
|
(Earliest)
J:31505
Holers VM et al.,
"Molecular cloning of a murine fibronectin receptor and its expression during inflammation. Expression of VLA-5 is increased in activated peritoneal macrophages in a manner discordant from major histocompatibility complex class II."
J Exp Med 1989 May 1;169(5):1589-605
(Latest)
J:152968
Bazigou E et al.,
"Integrin-alpha9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis."
Dev Cell 2009 Aug;17(2):175-86
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All references(74)
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Other
accession IDs
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MGD-MRK-11483, MGD-MRK-9851
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