Symbol
Name
ID
|
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Synonyms
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VLA-4 receptor, alpha 4 subunit
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Genetic Map
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Sequence Map
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Mammalian
homology
|
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Sequences
|
All sequences(65)
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Alleles
and
phenotypes
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All alleles(6) :
Targeted, knock-out(1)
Targeted, other(5)
| Mice homozygous for disruptions in this gene exhibit embryonic lethality either due to failure of chorioallantoic fusion or cardiac abnormalities, including hemorrhage around the heart and defects in epicardium formation. |
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Polymorphisms
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SNPs within 2kb(546 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
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Expression
|
Literature Summary: (31 records)
Data Summary:
Assays (9)
Results (195)
Tissues (178)
Images (43)
Theiler Stages: 1,3,4,13,15,18,19,20,22,23,28
| |
Assay Type |
Assays |
|
Results |
| |
RT-PCR |
2 |
|
60 |
| |
RNA in situ |
2 |
|
96 |
| |
Immunohistochemistry |
5 |
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39 |
cDNA source data(75)
External Resources:
Allen Brain Atlas
GEO
|
Molecular
reagents
|
All nucleic(101)
Genomic(17)
cDNA(81)
Primer pair(3)
Antibodies(2)
Microarray probesets(4)
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Other database
links
|
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Protein
domains
|
| InterPro ID |
Description |
| IPR000413 |
Integrin alpha chain |
| IPR013513 |
Integrin alpha chain, C-terminal, cytoplasmic region |
| IPR013517 |
FG-GAP |
| IPR013519 |
Integrin alpha beta-propellor |
| IPR013649 |
Integrin alpha-2 |
| IPR018184 |
Integrin alpha chain, C-terminal cytoplasmic region, conserved site |
Graphical View
of Protein Domain Structure
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References
|
(Earliest)
J:9952
Holzmann B et al.,
"Peyer's patch-specific lymphocyte homing receptors consist of a VLA-4-like alpha chain associated with either of two integrin beta chains, one of which is novel."
EMBO J 1989 Jun;8(6):1735-41
(Latest)
J:152968
Bazigou E et al.,
"Integrin-alpha9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis."
Dev Cell 2009 Aug;17(2):175-86
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All references(88)
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Other
accession IDs
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MGD-MRK-11482
|
