Symbol
Name
ID
|
|
|
STS
|
D5Mit44,D5Nds8
|
|
Synonyms
|
Il-6
|
|
Genetic Map
|
|
|
Sequence Map
|
|
Mammalian
homology
|
|
|
Sequences
|
All sequences(28)
|
Alleles
and
phenotypes
|
All alleles(3) :
Targeted, knock-out(3)
| Homozygous null mutants show impaired immune response to pathogens, decreased T cell numbers and resistance to plasma cell neoplasia. They are defective in wound healing and liver regeneration and show increased emotionality and high bone turnover rate. |
|
|
Polymorphisms
|
All PCR and RFLP(17) :
PCR(6)
RFLP(11)
SNPs within 2kb(53 from dbSNP Build 128)
|
Gene Ontology
(GO)
classifications
|
|
|
Expression
|
Literature Summary: (21 records)
Data Summary:
Assays (5)
Results (87)
Tissues (48)
Theiler Stages: 16,18,20,21,22,23,24,25,26,28
| |
Assay Type |
Assays |
|
Results |
| |
RT-PCR |
3 |
|
72 |
| |
Nuclease S1 |
1 |
|
6 |
| |
Northern blot |
1 |
|
9 |
cDNA source data(17)
External Resources:
Allen Brain Atlas
GENSAT
GEO
|
Molecular
reagents
|
All nucleic(37)
Genomic(5)
cDNA(17)
Primer pair(9)
Other(6)
Microarray probesets(2)
|
Other database
links
|
|
Protein
domains
|
Graphical View
of Protein Domain Structure
|
|
References
|
(Earliest)
J:9408
Chiu CP et al.,
"Multiple biological activities are expressed by a mouse interleukin 6 cDNA clone isolated from bone marrow stromal cells."
Proc Natl Acad Sci U S A 1988 Oct;85(19):7099-103
(Latest)
J:154176
Das J et al.,
"Transforming growth factor beta is dispensable for the molecular orchestration of Th17 cell differentiation."
J Exp Med 2009 Oct 26;206(11):2407-16
|
All references(551)
|
Other
accession IDs
|
MGD-MRK-11357, MGD-MRK-11391
|
