Symbol
Name
ID
|
|
|
STS
|
D5Mit44,D5Nds8
|
|
Synonyms
|
Il-6
|
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Genetic Map
|
|
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Sequence Map
|
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Mammalian
homology
|
|
|
Sequences
|
All sequences(28)
|
Alleles
and
phenotypes
|
All alleles(3) :
Targeted, knock-out(3)
| Homozygous null mutants show impaired immune response to pathogens, decreased T cell numbers and resistance to plasma cell neoplasia. They are defective in wound healing and liver regeneration and show increased emotionality and high bone turnover rate. |
|
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Polymorphisms
|
All PCR and RFLP(17) :
PCR(6)
RFLP(11)
SNPs within 2kb(53 from dbSNP Build 128)
|
Gene Ontology
(GO)
classifications
|
|
|
Expression
|
Literature Summary: (21 records)
Data Summary:
Assays (5)
Results (87)
Tissues (48)
Theiler Stages: 16,18,20,21,22,23,24,25,26,28
| |
Assay Type |
Assays |
|
Results |
| |
RT-PCR |
3 |
|
72 |
| |
Nuclease S1 |
1 |
|
6 |
| |
Northern blot |
1 |
|
9 |
cDNA source data(19)
External Resources:
Allen Brain Atlas
GENSAT
GEO
ArrayExpress
|
Molecular
reagents
|
All nucleic(39)
Genomic(5)
cDNA(19)
Primer pair(9)
Other(6)
Microarray probesets(2)
|
Other database
links
|
|
Protein
domains
|
Graphical View
of Protein Domain Structure
|
|
References
|
(Earliest)
J:9408
Chiu CP et al.,
"Multiple biological activities are expressed by a mouse interleukin 6 cDNA clone isolated from bone marrow stromal cells."
Proc Natl Acad Sci U S A 1988 Oct;85(19):7099-103
(Latest)
J:156484
Kimura A et al.,
"The absence of interleukin-6 enhanced arsenite-induced renal injury by promoting autophagy of tubular epithelial cells with aberrant extracellular signal-regulated kinase activation."
Am J Pathol 2010 Jan;176(1):40-50
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All references(564)
|
Other
accession IDs
|
MGD-MRK-11357, MGD-MRK-11391
|
Analysis Tools
MGI BioMart
