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Il4 Gene Detail
 Symbol
Name
ID
Il4
interleukin 4
MGI:96556


Nomenclature History
Synonyms Il-4
Genetic Map
Chromosome 11
29.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 43)

Sequence Map
Chr11:53416484-53432171 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; pig, domestic; rat; sheep    (Mammalian Orthology)
Comparative Map (Mouse/Human Il4 ± 2 cM)
Protein SuperFamily: interleukin-4
TreeFam: TF336383
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000005642 VEGA Gene Model | MGI Sequence Detail 15688 C57BL/6J ± Kb
transcript NR_027491 RefSeq | MGI Sequence Detail 624 C57BL/6
polypeptide P07750 UniProt | EBI | MGI Sequence Detail 140 Not Applicable
For the selected sequences
All sequences(27)
Alleles
and
phenotypes
All alleles(14) : Targeted, knock-out(7) Targeted, other(7)
Associated Human Diseases (2)   Alleles Annotated to Human Diseases (1)  
Polymorphisms All PCR and RFLP(9) : PCR(4) RFLP(5) SNPs within 2kb(131 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process B cell activation, cholesterol metabolic process...
Component extracellular region, extracellular space...
Function cytokine activity, cytokine receptor binding...
External Resources: FuncBase
Expression Literature Summary: (13 records)
Data Summary: Assays (6)    Results (50)    Tissues (26)    Images (2)
Theiler Stages: 13,17,20,21,22,23,24,25,26,28
  Assay Type Assays   Results
      RT-PCR 5   44
      Nuclease S1 1   6
cDNA source data(14)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents
All nucleic(36) Genomic(11) cDNA(14) Primer pair(6) Other(5)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000000869
DoTS DT.530186, DT.94153869
Consensus CDS Project CCDS24682.1
UniGene 276360
DFCI TC1588033, TC1652072
NIA Mouse Gene Index U032765
Entrez Gene 16189
VEGA Gene Model OTTMUSG00000005642
International Mouse Knockout Project Status Il4
Protein
domains
InterPro ID Description
IPR001325 Interleukin-4/interleukin-13
IPR002354 Interleukin 4
IPR009079 Four-helical cytokine-like, core
IPR018096 Interleukin-4/interleukin-13, conserved site
Graphical View of Protein Domain Structure
References
(Earliest) J:39743 Howard M et al., "Identification of a T cell-derived b cell growth factor distinct from interleukin 2." J Exp Med 1982 Mar 1;155(3):914-23
(Latest) J:156317 Varin A et al., "Alternative activation of macrophages by IL-4 impairs phagocytosis of pathogens but potentiates microbial-induced signalling and cytokine secretion." Blood 2010 Jan 14;115(2):353-62
All references(648)
Other
accession IDs
MGD-MRK-11355, MGD-MRK-11385

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/06/2010
MGI_4.32
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The Jackson Laboratory