Symbol
Name
ID
|
|
|
STS
|
D3Mit21,D3Ncvs11,D3Nds27,D3Nds6
|
|
Synonyms
|
IL-2
|
|
Genetic Map
|
|
|
Sequence Map
|
|
Mammalian
homology
|
|
|
Sequences
|
All sequences(58)
|
Alleles
and
phenotypes
|
All alleles(4) :
Targeted, knock-out(1)
Targeted, other(2)
Spontaneous(1)
| Homozygous null mutants develop adult onset autoimmune disease, with 50% mortality by 9 weeks due to hemolytic anemia. Survivors develop inflammatory bowl disease/colitis. Immune system dysregulation and CD4+ T-cell overproduction may be responsible. |
|
|
Polymorphisms
|
All PCR and RFLP(9) :
PCR(7)
RFLP(2)
SNPs within 2kb(130 from dbSNP Build 128)
|
Gene Ontology
(GO)
classifications
|
|
|
Expression
|
Literature Summary: (9 records)
Data Summary:
Assays (4)
Results (30)
Tissues (16)
Theiler Stages: 21,22,23,24,25,26
| |
Assay Type |
Assays |
|
Results |
| |
RT-PCR |
4 |
|
30 |
cDNA source data(15)
External Resources:
GEO
ArrayExpress
|
Molecular
reagents
|
All nucleic(41)
Genomic(13)
cDNA(15)
Primer pair(10)
Other(3)
Microarray probesets(2)
|
Other database
links
|
|
Protein
domains
|
| InterPro ID |
Description |
| IPR000779 |
Interleukin-2 |
| IPR009079 |
Four-helical cytokine-like, core |
Graphical View
of Protein Domain Structure
|
|
References
|
(Earliest)
J:7697
Fuse A et al.,
"Organization and structure of the mouse interleukin-2 gene."
Nucleic Acids Res 1984 Dec 21;12(24):9323-31
(Latest)
J:155313
Oldenhove G et al.,
"Decrease of Foxp3+ Treg cell number and acquisition of effector cell phenotype during lethal infection."
Immunity 2009 Nov 20;31(5):772-86
|
All references(332)
|
Other
accession IDs
|
MGD-MRK-11353, MGD-MRK-11374
|
Analysis Tools
MGI BioMart
