Symbol
Name
ID
|
|
|
STS
|
D2Mit135,D2Nds3
|
|
Synonyms
|
IL-1B, IL-1beta
|
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Genetic Map
|
|
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Sequence Map
|
|
Mammalian
homology
|
|
|
Sequences
|
All sequences(22)
|
Alleles
and
phenotypes
|
All alleles(3) :
Targeted, knock-out(2)
Targeted, other(1)
| Homozygous null mutants show impaired contact hypersensitivity and reduced acute-phase inflammatory response. Lung tumors and metastases of B16 melanoma do not occur in null mutant mice, suggesting inability to support tumor invasiveness and angiogenesis. |
|
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Polymorphisms
|
All PCR and RFLP(9) :
PCR(7)
RFLP(2)
SNPs within 2kb(94 from dbSNP Build 128)
|
Gene Ontology
(GO)
classifications
|
|
|
Expression
|
Literature Summary: (12 records)
Data Summary:
Assays (7)
Results (96)
Tissues (63)
Theiler Stages: 2,3,4,16,17,18,19,20,21,22,23,24,25,26,28
| |
Assay Type |
Assays |
|
Results |
| |
RT-PCR |
7 |
|
96 |
cDNA source data(13)
External Resources:
Allen Brain Atlas
GEO
|
Molecular
reagents
|
All nucleic(27)
Genomic(4)
cDNA(13)
Primer pair(8)
Other(2)
Microarray probesets(2)
|
Other database
links
|
|
Protein
domains
|
Graphical View
of Protein Domain Structure
|
|
References
|
(Earliest)
J:8581
Telford JL et al.,
"The murine interleukin 1 beta gene: structure and evolution."
Nucleic Acids Res 1986 Dec 22;14(24):9955-63
(Latest)
J:153779
Kovalenko A et al.,
"Caspase-8 deficiency in epidermal keratinocytes triggers an inflammatory skin disease."
J Exp Med 2009 Sep 28;206(10):2161-77
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All references(245)
|
Other
accession IDs
|
MGD-MRK-11352, MGD-MRK-11367
|
