Symbol
Name
ID
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Synonyms
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cytokine synthesis inhibitory factor, IL-10
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Genetic Map
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Sequence Map
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Mammalian
homology
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Sequences
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All sequences(17)
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Alleles
and
phenotypes
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All alleles(7) :
Targeted, knock-out(2)
Targeted, other(5)
| Homozygotes for a targeted null mutation exhibit retarded growth, anemia, chronic enterocolitis, a high incidence of colorectal adenocarcinomas, and altered responses to various infectious organisms such as Mycobacterium bovis and Leishmania donovani. |
Phenotype Images (1)
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Polymorphisms
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RFLP(1)
SNPs within 2kb(69 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
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Expression
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Literature Summary: (4 records)
Data Summary:
Assays (2)
Results (11)
Tissues (6)
Images (1)
Theiler Stages: 22,23,24,25,26,28
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Assay Type |
Assays |
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Results |
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RT-PCR |
2 |
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11 |
cDNA source data(7)
External Resources:
Allen Brain Atlas
GEO
ArrayExpress
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Molecular
reagents
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All nucleic(12)
Genomic(3)
cDNA(7)
Primer pair(2)
Microarray probesets(2)
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Other database
links
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Protein
domains
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Graphical View
of Protein Domain Structure
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References
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(Earliest)
J:14590
Fiorentino DF et al.,
"Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones."
J Exp Med 1989 Dec 1;170(6):2081-95
(Latest)
J:155683
Lu L et al.,
"Synergistic effect of TGF-beta superfamily members on the induction of Foxp3+ Treg."
Eur J Immunol 2010 Jan;40(1):142-52
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All references(600)
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Other
accession IDs
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MGD-MRK-11347, MGD-MRK-11361
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Analysis Tools
MGI BioMart
