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Hadh Gene Detail
 Symbol
Name
ID
Hadh
hydroxyacyl-Coenzyme A dehydrogenase
MGI:96009


Nomenclature History
Synonyms Hadhsc
Genetic Map
Chromosome 3
Syntenic
 
Mapping data( 2)
Sequence Map
Chr3:130936337-130975019 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Protein SuperFamily: 3-hydroxyacyl-CoA dehydrogenase
TreeFam: TF300886
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000028850 VEGA Gene Model | MGI Sequence Detail 38683 C57BL/6J ± Kb
transcript NM_008212 RefSeq | MGI Sequence Detail 1720 C57BL/6
polypeptide Q61425 UniProt | EBI | MGI Sequence Detail 314 Not Applicable
For the selected sequences
All sequences(32)
Alleles
and
phenotypes
All alleles(2) : Gene trapped(2)
Polymorphisms SNPs within 2kb(323 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process fatty acid metabolic process, lipid metabolic process...
Component mitochondrial inner membrane, mitochondrion...
Function 3-hydroxyacyl-CoA dehydrogenase activity, binding...
External Resources: FuncBase
Expression Literature Summary: (3 records)
Data Summary: Assays (2)    Results (54)    Tissues (51)    Images (7)
Theiler Stages: 23,24,26,28
  Assay Type Assays   Results
      RT-PCR 1   46
      RNA in situ 1   8
cDNA source data(203)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents
All nucleic(206) cDNA(204) Primer pair(2)
Microarray probesets(2)
Pathways
fatty acid β-oxidation I
fatty acid β-oxidation II (core pathway)
glutaryl-CoA degradation
3-hydroxypropionate/4-hydroxybutyrate cycle
tryptophan degradation III (eukaryotic)
Other database
links
EC 1.1.1.35
Ensembl Gene Model ENSMUSG00000027984
DoTS DT.537104, DT.99863760
Consensus CDS Project CCDS38640.1
UniGene 260164
DFCI TC1573429
NIA Mouse Gene Index U024654
Entrez Gene 15107
VEGA Gene Model OTTMUSG00000028850
International Mouse Knockout Project Status Hadh
Protein
domains
InterPro ID Description
IPR006108 3-hydroxyacyl-CoA dehydrogenase, C-terminal
IPR006176 3-hydroxyacyl-CoA dehydrogenase, NAD binding
IPR006180 3-hydroxyacyl-CoA dehydrogenase, conserved site
IPR008927 6-phosphogluconate dehydrogenase, C-terminal-like
IPR013328 Dehydrogenase, multihelical
IPR016040 NAD(P)-binding domain
Graphical View of Protein Domain Structure
References
(Earliest) J:19568 Nomura M et al., "Isolation and characterization of retinoic acid-inducible cDNA clones in F9 cells: one of the early inducible clones encodes a novel protein sharing several highly homologous regions with a Drosophila polyhomeotic protein." Differentiation 1994 Jun;57(1):39-50
(Latest) J:151002 Pagliarini DJ et al., "A mitochondrial protein compendium elucidates complex I disease biology." Cell 2008 Jul 11;134(1):112-23
All references(15)
Other
accession IDs
MGD-MRK-10609, MGI:2139565, MGI:2139879, MGI:2140013

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
02/06/2010
MGI_4.32
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