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Got1 Gene Detail
 Symbol
Name
ID
Got1
glutamate oxaloacetate transaminase 1, soluble
MGI:95791


Nomenclature History
Synonyms cAspAT, cytosolic aspartate aminotransferase, Got-1
Genetic Map
Chromosome 19
37.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 18)

Sequence Map
Chr19:43574242-43599095 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; lemur, mouse; pig, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Got1 ± 2 cM)
Protein SuperFamily: aspartate aminotransferase/aromatic aminotransferase, tatA type
TreeFam: TF314089
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000023608 VEGA Gene Model | MGI Sequence Detail 24854 C57BL/6J ± Kb
transcript NM_010324 RefSeq | MGI Sequence Detail 2065 C57BL/6
polypeptide P05201 UniProt | EBI | MGI Sequence Detail 413 Not Applicable
For the selected sequences
All sequences(37)
Alleles
and
phenotypes
All alleles(42) : Gene trapped(42)
Polymorphisms SNPs within 2kb(177 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(18)
Process aspartate biosynthetic process, biosynthetic process...
Component cytoplasm, cytosol...
Function catalytic activity, L-aspartate:2-oxoglutarate aminotransferase activity...
This is a GO Consortium Reference Genome Project gene.
External Resources: MouseFunc
Expression Literature Summary: (2 records)
Data Summary: Assays (3)    Results (106)    Tissues (97)    Images (18)
Theiler Stages: 22,26,28
  Assay Type Assays   Results
      RNA in situ 1   93
      Northern blot 2   13
cDNA source data(227)
External Resources: Allen Brain Atlas  GEO 
Molecular
reagents
All nucleic(234) Genomic(5) cDNA(228) Primer pair(1)
Microarray probesets(2)
Pathways
aspartate degradation I
aspartate biosynthesis
L-cysteine degradation I
glutamine degradation II
glutamate degradation VII
4-hydroxyproline degradation I
superpathway of methionine degradation
Other database
links
EC 2.6.1.1
Ensembl Gene Model ENSMUSG00000025190
DoTS DT.536877
UniGene 19039
DFCI TC1572430, TC1590523, TC1775861
NIA Mouse Gene Index U039061
Entrez Gene 14718
VEGA Gene Model OTTMUSG00000023608
International Mouse Knockout Project Status Got1
Protein
domains
InterPro ID Description
IPR000796 Aspartate/other aminotransferase
IPR004838 Aminotransferases, class-I, pyridoxal-phosphate-binding site
IPR004839 Aminotransferase, class I/II
IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1
IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2
IPR015424 Pyridoxal phosphate-dependent transferase, major domain
Graphical View of Protein Domain Structure
References
(Earliest) J:5163 DeLorenzo RJ et al., "Glutamate oxalate transaminase (GOT) genetics in Mus musculus: linkage, polymorphism, and phenotypes of the Got-2 and Got-1 loci." Biochem Genet 1970 Apr;4(2):259-73
(Latest) J:124582 Tordjman J et al., "Cytosolic aspartate aminotransferase, a new partner in adipocyte glyceroneogenesis and an atypical target of thiazolidinedione." J Biol Chem 2007 Aug 10;282(32):23591-602
All references(25)
Other
accession IDs
MGD-MRK-10213, MGD-MRK-10215, MGI:2147593

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/20/2009
MGI_4.31
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