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Gnrh1 Gene Detail
 Symbol
Name
ID
Gnrh1
gonadotropin releasing hormone 1
MGI:95789


Nomenclature History
STS D14Nds6
Synonyms LHRH, LNRH
Genetic Map
Chromosome 14
30.5 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 12)

Sequence Map
Chr14:68364403-68367348 bp, + strand
(From NCBI annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Gnrh1 ± 2 cM)
Protein SuperFamily: gonadoliberin
TreeFam: TF330934
Sequences
Representative Sequences Length Strain/Species Flank
genomic 14714 NCBI Gene Model | MGI Sequence Detail 2946 C57BL/6J ± Kb
transcript NM_008145 RefSeq | MGI Sequence Detail 532 C57BL/6
polypeptide P13562 UniProt | EBI | MGI Sequence Detail 90 Not Applicable
For the selected sequences
All sequences(16)
Alleles
and
phenotypes
All alleles(2) : Gene trapped(1) Spontaneous(1)
Homozygous mutants are characterized by the failure of the sex organs to develop postnatally, resulting in sterility in both males and females. Deficiency in hypothalamic GnRH results in deficiencies of LH, FSH and gonadal steroids.
Associated Human Diseases (1)   Alleles Annotated to Human Diseases (1)   Phenotype Images (1)  
Polymorphisms PCR(4) SNPs within 2kb(57 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(9)
Process multicellular organismal development, regulation of gene expression...
Component extracellular region
Function gonadotropin hormone-releasing hormone activity, hormone activity...
External Resources: MouseFunc
Expression Literature Summary: (52 records)
Data Summary: Assays (3)    Results (28)    Tissues (12)    Images (18)
Theiler Stages: 20,21,22,23
  Assay Type Assays   Results
      RNA in situ 1   1
      Immunohistochemistry 2   27
cDNA source data(7)
External Resources: Allen Brain Atlas  GEO 
Molecular
reagents
All nucleic(14) Genomic(4) cDNA(7) Primer pair(2) Other(1) Antibodies(2)
Microarray probesets(1)
Other database
links
Ensembl Gene Model ENSMUSG00000015812
DoTS DT.103545888
UniGene 358309
DFCI TC1649990
NIA Mouse Gene Index U015799
Entrez Gene 14714
International Mouse Knockout Project Status Gnrh1
Protein
domains
InterPro ID Description
IPR002012 Gonadotropin-releasing hormone
IPR004079 Gonadoliberin I precursor
IPR019792 Gonadoliberin I
Graphical View of Protein Domain Structure
References
(Earliest) J:5877 Cattanach BM et al., "Gonadotrophin-releasing hormone deficiency in a mutant mouse with hypogonadism." Nature 1977 Sep 22;269(5626):338-40
(Latest) J:153209 Tissir F et al., "DeltaNp73 regulates neuronal survival in vivo." Proc Natl Acad Sci U S A 2009 Sep 29;106(39):16871-6
All references(175)
Other
accession IDs
MGD-MRK-10208, MGD-MRK-10915

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/20/2009
MGI_4.31
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The Jackson Laboratory