About   Help   FAQ
Tour our new Quick Search
Gli3 Gene Detail
 Symbol
Name
ID
Gli3
GLI-Kruppel family member GLI3
MGI:95729

Nomenclature History
Synonyms Bph, brachyphalangy
Genetic Map
Chromosome 13
14.0 cM, cytoband A2
Detailed Genetic Map ± 1 cM
 
Mapping data( 38)

Sequence Map
Chr13:15555068-15821859 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Gli3 ± 2 cM)
Protein SuperFamily: gli transforming protein
TreeFam: TF350216
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000024401 VEGA Gene Model | MGI Sequence Detail 266792 C57BL/6J ± Kb
transcript NM_008130 RefSeq | MGI Sequence Detail 8428 C57BL/6
polypeptide Q61602 UniProt | EBI | MGI Sequence Detail 1583 Not Applicable
For the selected sequences
All sequences(33)
Alleles
and
phenotypes 		All alleles(19) : Targeted, knock-out(2) Targeted, other(3) Gene trapped(2) Transgenic(2) Spontaneous(4) Chemically induced(1) Radiation induced(5)
Homozygous mutants die perinatally with gross polydactyly, multiple craniofacial defects, and frequently, exencephaly. Heterozygotes exhibit enlarged interfrontal bone and extra preaxial digits.
Associated Human Diseases (2)   Alleles Annotated to Human Diseases (2)   Phenotype Images (3)  
Polymorphisms All PCR and RFLP(5) : PCR(2) RFLP(3) SNPs within 2kb(1321 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(80)
Process anatomical structure development, anatomical structure formation involved in morphogenesis...
Component cilium, cytoplasm...
Function chromatin binding, DNA binding...
This is a GO Consortium Reference Genome Project gene.
External Resources: MouseFunc
Expression Literature Summary: (186 records)
Data Summary: Assays (39)    Results (212)    Tissues (132)    Images (72)
Theiler Stages: 2,3,4,5,13,15,16,17,18,19,20,21,22,23,24,25,28
  Assay Type Assays   Results
      Western blot 5   12
      RT-PCR 5   35
      RNA in situ 23   150
      Immunohistochemistry 2   5
      Northern blot 3   8
      RNase protection 1   2
cDNA source data(86)
External Resources: Allen Brain Atlas  GENSAT  GEO 
Molecular
reagents 		All nucleic(109) Genomic(4) cDNA(90) Primer pair(8) Other(7) Antibodies(6)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000021318
DoTS DT.101146591, DT.485325, DT.489069, DT.97355264
UniGene 5098
DFCI TC1584775, TC1598037
NIA Mouse Gene Index U014564
Entrez Gene 14634
VEGA Gene Model OTTMUSG00000024401
International Mouse Knockout Project Status Gli3
Protein
domains
InterPro ID Description
IPR007087 Zinc finger, C2H2-type
IPR013087 Zinc finger, C2H2-type/integrase, DNA-binding
IPR015880 Zinc finger, C2H2-like
Graphical View of Protein Domain Structure
References
(Earliest) J:12947 Lyon MF et al., "The overall rates of dominant and recessive lethal and visible mutation induced by spermatogonial X-irradiation of mice." Genet Res 1964;5():448-467
(Latest) J:154130 Han YG et al., "Dual and opposing roles of primary cilia in medulloblastoma development." Nat Med 2009 Sep;15(9):1062-5
All references(325)
Other
accession IDs 		MGD-MRK-10107, MGD-MRK-1107, MGD-MRK-13222, MGD-MRK-15835, MGD-MRK-1615, MGI:2145311, MGI:2145364
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support. 		last database update
11/20/2009
MGI_4.31
Web browser compatibility 		The Jackson Laboratory