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Fyn Gene Detail
 Symbol
Name
ID
Fyn
Fyn proto-oncogene
MGI:95602

Nomenclature History
Synonyms Src Kinase p59
Genetic Map
Chromosome 10
25.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 16)

Sequence Map
Chr10:39088661-39285187 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; cat, domestic; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Fyn ± 2 cM)
Protein SuperFamily: tyrosine-protein kinase, proto-oncogene SRC type
TreeFam: TF351634
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000034130 VEGA Gene Model | MGI Sequence Detail 196527 C57BL/6J ± Kb
transcript NM_001122893 RefSeq | MGI Sequence Detail 3544 C57BL/6
polypeptide P39688 UniProt | EBI | MGI Sequence Detail 537 Not Applicable
For the selected sequences
All sequences(44)
Alleles
and
phenotypes 		All alleles(11) : Targeted, knock-out(3) Targeted, other(1) Gene trapped(7)
Different targeted allele homozygotes show different defects, including seizure susceptibility, anxiety, impaired suckling, myelination, LTP and spatial learning, and defects in immune system, circadian rhythm, testes weight and olfactory bulb formation.
Polymorphisms RFLP(3) SNPs within 2kb(1345 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process activated T cell proliferation, cell surface receptor linked signal transduction...
Component cytosol, membrane...
Function ATP binding, kinase activity...
External Resources: FuncBase
Expression Literature Summary: (26 records)
Data Summary: Assays (7)    Results (44)    Tissues (33)    Images (2)
Theiler Stages: 21,22,23,24,25,26,28
  Assay Type Assays   Results
      Western blot 1   2
      RNA in situ 3   17
      Northern blot 3   25
cDNA source data(19)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(31) Genomic(3) cDNA(24) Primer pair(1) Other(3) Antibodies(1)
Microarray probesets(3)
Other database
links
EC 2.7.10.2
Ensembl Gene Model ENSMUSG00000019843
DoTS DT.101277672, DT.101725436, DT.534255, DT.94309707, DT.99840621
Consensus CDS Project CCDS23788.1
DFCI TC1575770, TC1588628, TC1603454, TC1627441, TC1633770
NIA Mouse Gene Index U011411
Entrez Gene 14360
VEGA Gene Model OTTMUSG00000034130
International Mouse Knockout Project Status Fyn
Protein
domains
InterPro ID Description
IPR000719 Protein kinase, catalytic domain
IPR000980 SH2 motif
IPR001245 Tyrosine-protein kinase, catalytic domain
IPR001452 Src homology-3 domain
IPR008266 Tyrosine-protein kinase, active site
IPR011009 Protein kinase-like domain
IPR017441 Protein kinase, ATP binding site
IPR020473 Src homology-3, region
IPR020635 Tyrosine-protein kinase, subgroup, catalytic domain
IPR020685 Tyrosine-protein kinase
IPR020745 Tyrosine-protein kinase, non-receptor Fyn
Graphical View of Protein Domain Structure
References
(Earliest) J:31022 Kawakami T et al., "Isolation and oncogenic potential of a novel human src-like gene." Mol Cell Biol 1986 Dec;6(12):4195-201
(Latest) J:154974 Knezevic N et al., "The G protein betagamma subunit mediates reannealing of adherens junctions to reverse endothelial permeability increase by thrombin." J Exp Med 2009 Nov 23;206(12):2761-77
All references(231)
Other
accession IDs 		MGD-MRK-9909, MGI:2143602, MGI:2143864
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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