Symbol
Name
ID
|
|
|
Synonyms
|
APO-1, CD95, TNFR6, Tnfrsf6
|
|
Genetic Map
|
|
|
Sequence Map
|
|
Mammalian
homology
|
|
|
Sequences
|
All sequences(33)
|
Alleles
and
phenotypes
|
All alleles(8) :
Targeted, knock-out(2)
Targeted, other(4)
Spontaneous(2)
| Mutations in this locus affect immune function and homozygotes show varying severity of lymphadenopathy, splenomegaly, lymphocytic infiltrations, elevated immunoglobulin levels, autoantibodies, impaired clonal deletion of T cells, and lupus-like disease. |
Associated Human Diseases (5)
Alleles Annotated to Human Diseases (4)
Phenotype Images (2)
|
|
Polymorphisms
|
All PCR and RFLP(5) :
PCR(1)
RFLP(4)
SNPs within 2kb(256 from dbSNP Build 128)
|
Gene Ontology
(GO)
classifications
|
|
|
Expression
|
Literature Summary: (19 records)
Data Summary:
Assays (2)
Results (52)
Tissues (47)
Images (1)
Theiler Stages: 23,26,28
| |
Assay Type |
Assays |
|
Results |
| |
Western blot |
1 |
|
6 |
| |
RT-PCR |
1 |
|
46 |
cDNA source data(24)
External Resources:
Allen Brain Atlas
GEO
ArrayExpress
|
Molecular
reagents
|
All nucleic(31)
Genomic(2)
cDNA(24)
Primer pair(2)
Other(3)
Antibodies(1)
Microarray probesets(6)
|
Other database
links
|
|
Protein
domains
|
Graphical View
of Protein Domain Structure
|
|
References
|
(Earliest)
J:13747
Murphy ED et al.,
"Lymphoproliferation (lpr)."
Mouse News Lett 1978;58():47
(Latest)
J:155557
Chen L et al.,
"Deficiency in activation-induced cytidine deaminase promotes systemic autoimmunity in lpr mice on a C57BL/6 background."
Clin Exp Immunol 2009 Nov 18;():
|
All references(923)
|
Other
accession IDs
|
MGD-MRK-11878, MGD-MRK-9711, MGI:2147489
|
Analysis Tools
MGI BioMart
