Symbol
Name
ID
|
|
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Synonyms
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APO-1, CD95, TNFR6, Tnfrsf6
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Genetic Map
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Sequence Map
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Mammalian
homology
|
|
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Sequences
|
All sequences(33)
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Alleles
and
phenotypes
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All alleles(8) :
Targeted, knock-out(2)
Targeted, other(4)
Spontaneous(2)
| Mutations in this locus affect immune function and homozygotes show varying severity of lymphadenopathy, splenomegaly, lymphocytic infiltrations, elevated immunoglobulin levels, autoantibodies, impaired clonal deletion of T cells, and lupus-like disease. |
Associated Human Diseases (5)
Alleles Annotated to Human Diseases (4)
Phenotype Images (2)
|
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Polymorphisms
|
All PCR and RFLP(5) :
PCR(1)
RFLP(4)
SNPs within 2kb(256 from dbSNP Build 128)
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Gene Ontology
(GO)
classifications
|
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Expression
|
Literature Summary: (19 records)
Data Summary:
Assays (2)
Results (52)
Tissues (47)
Images (1)
Theiler Stages: 23,26,28
| |
Assay Type |
Assays |
|
Results |
| |
Western blot |
1 |
|
6 |
| |
RT-PCR |
1 |
|
46 |
cDNA source data(24)
External Resources:
Allen Brain Atlas
GEO
|
Molecular
reagents
|
All nucleic(31)
Genomic(2)
cDNA(24)
Primer pair(2)
Other(3)
Antibodies(1)
Microarray probesets(6)
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Other database
links
|
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Protein
domains
|
Graphical View
of Protein Domain Structure
|
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References
|
(Earliest)
J:13747
Murphy ED et al.,
"Lymphoproliferation (lpr)."
Mouse News Lett 1978;58():47
(Latest)
J:154080
Rotolo JA et al.,
"Cytolytic T cells induce ceramide-rich platforms in target cell membranes to initiate graft-versus-host disease."
Blood 2009 Oct 22;114(17):3693-706
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All references(915)
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Other
accession IDs
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MGD-MRK-11878, MGD-MRK-9711, MGI:2147489
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