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Dvl1 Gene Detail
 Symbol
Name
ID
Dvl1
dishevelled, dsh homolog 1 (Drosophila)
MGI:94941


Nomenclature History
Genetic Map
Chromosome 4
82.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 17)

Sequence Map
Chr4:155221511-155233412 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Dvl1 ± 2 cM)
Protein SuperFamily: segment polarity protein dishevelled homolog DVL
TreeFam: TF318198
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000010890 VEGA Gene Model | MGI Sequence Detail 11902 C57BL/6J ± Kb
transcript NM_010091 RefSeq | MGI Sequence Detail 3365 -
polypeptide P51141 UniProt | EBI | MGI Sequence Detail 695 Not Applicable
For the selected sequences
All sequences(34)
Alleles
and
phenotypes
All alleles(1) : Targeted, knock-out(1)
Homozygous targeted mutants are viable and fertile, but show a number of behavioral changes including deficient nest-building, less huddling contact during sleep, reduced subordinate responses, and other social interaction deficits.
Polymorphisms PCR(3) SNPs within 2kb(79 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process dendrite morphogenesis, intracellular signaling cascade...
Component cytoplasm, cytoplasmic membrane-bounded vesicle...
Function protein binding, signal transducer activity...
External Resources: FuncBase
Expression Literature Summary: (14 records)
Data Summary: Assays (4)    Results (33)    Tissues (22)    Images (11)
Theiler Stages: 1,2,3,4,5,19,20,22,24,26,28
  Assay Type Assays   Results
      RT-PCR 2   20
      RNA in situ 1   12
      Immunohistochemistry 1   1
cDNA source data(76)
External Resources: Allen Brain Atlas  GENSAT  GEO  ArrayExpress 
Molecular
reagents
All nucleic(85) Genomic(4) cDNA(77) Primer pair(4) Antibodies(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000029071
DoTS DT.489555, DT.87058099, DT.91414321, DT.94403322, DT.99857711
Consensus CDS Project CCDS19045.1
UniGene 3400
PDB 1FSH, 1MC7, 2KAW
DFCI TC1576035, TC1602954, TC1606858, TC1613797, TC1775336
NIA Mouse Gene Index U005222
Entrez Gene 13542
VEGA Gene Model OTTMUSG00000010890
International Mouse Knockout Project Status Dvl1
Protein
domains
InterPro ID Description
IPR000591 DEP domain
IPR001158 DIX
IPR001478 PDZ/DHR/GLGF
IPR003351 Dishevelled protein
IPR008339 Dishevelled region
IPR008340 Dishevelled-1 protein
IPR011991 Winged helix repressor DNA-binding
IPR015506 Dishevelled related protein
Graphical View of Protein Domain Structure
References
(Earliest) J:2643 Beier DR et al., "Mapping genes in the mouse using single-strand conformation polymorphism analysis of recombinant inbred strains and interspecific crosses." Proc Natl Acad Sci U S A 1992 Oct 1;89(19):9102-6
(Latest) J:155488 Fujimura L et al., "Prickle promotes neurite outgrowth via the Dishevelled dependent pathway in C1300 cells." Neurosci Lett 2009 Dec 18;467(1):6-10
All references(55)
Other
accession IDs
MGD-MRK-8919

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
02/06/2010
MGI_4.32
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