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Acadvl Gene Detail
 Symbol
Name
ID
Acadvl
acyl-Coenzyme A dehydrogenase, very long chain
MGI:895149

Nomenclature History
Synonyms VLCAD
Genetic Map
Chromosome 11
38.0 cM, cytoband B2-B5
Detailed Genetic Map ± 1 cM
 
Mapping data( 5)

Sequence Map
Chr11:69823685-69828913 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Acadvl ± 2 cM)
TreeFam: TF105053
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000006027 VEGA Gene Model | MGI Sequence Detail 5229 C57BL/6J ± Kb
transcript NM_017366 RefSeq | MGI Sequence Detail 2158 C57BL/6
polypeptide P50544 UniProt | EBI | MGI Sequence Detail 656 Not Applicable
For the selected sequences
All sequences(22)
Alleles
and
phenotypes 		All alleles(2) : Targeted, knock-out(2)
Homozygous mutant animals exhibit mild steatosis, lipid accumulation in myocytes, increased fatigue, impaired temperature regulation, increased susceptibility to arrhythmia, accumulation of long-chain acylcarnitines, and lower free carnitine levels.
Associated Human Diseases (1)   Alleles Annotated to Human Diseases (2)  
Polymorphisms RFLP(1) SNPs within 2kb(51 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process fatty acid beta-oxidation using acyl-CoA dehydrogenase, fatty acid metabolic process...
Component membrane, mitochondrial inner membrane...
Function acyl-CoA dehydrogenase activity, FAD binding...
External Resources: FuncBase
Expression Literature Summary: (2 records)
Data Summary: Assays (2)    Results (28)    Tissues (21)
Theiler Stages: 10,18,23,25,28
  Assay Type Assays   Results
      Northern blot 2   28
cDNA source data(268)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents 		All nucleic(274) Genomic(4) cDNA(268) Primer pair(1) Other(1)
Microarray probesets(2)
Pathways
fatty acid β-oxidation I
Other database
links
Ensembl Gene Model ENSMUSG00000018574
DoTS DT.101245194, DT.537490
Consensus CDS Project CCDS24931.1
UniGene 18630
DFCI TC1572989, TC1600216
NIA Mouse Gene Index U158171
Entrez Gene 11370
VEGA Gene Model OTTMUSG00000006027
International Mouse Knockout Project Status Acadvl
Protein
domains
InterPro ID Description
IPR006089 Acyl-CoA dehydrogenase, conserved site
IPR006090 Acyl-CoA oxidase/dehydrogenase, type 1
IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain
IPR006092 Acyl-CoA dehydrogenase, N-terminal
IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal
IPR009100 Acyl-CoA dehydrogenase/oxidase
IPR013764 Acyl-CoA oxidase/dehydrogenase, type1/2, C-terminal
IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal
Graphical View of Protein Domain Structure
References
(Earliest) J:42861 Aoyama T et al., "A novel disease with deficiency of mitochondrial very-long-chain acyl-CoA dehydrogenase." Biochem Biophys Res Commun 1993 Mar 31;191(3):1369-72
(Latest) J:154719 Cox KB et al., "Cardiac hypertrophy in mice with long-chain acyl-CoA dehydrogenase or very long-chain acyl-CoA dehydrogenase deficiency." Lab Invest 2009 Dec;89(12):1348-54
All references(27)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/06/2010
MGI_4.32
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