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Scarb1 Gene Detail
 Symbol
Name
ID
Scarb1
scavenger receptor class B, member 1
MGI:893578


Nomenclature History
Synonyms Cd36l1, Cla-1, D5Ertd460e, Hlb398, SR-BI, Srb1, SRBI
Genetic Map
Chromosome 5
68.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 14)

Sequence Map
Chr5:125757457-125821464 bp, - strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; hamster, Chinese; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Scarb1 ± 2 cM)
Protein SuperFamily: lysosomal integral membrane protein II
TreeFam: TF317925
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000022742 VEGA Gene Model | MGI Sequence Detail 64008 C57BL/6J ± Kb
transcript NM_016741 RefSeq | MGI Sequence Detail 2512 FVB/N
polypeptide Q61009 UniProt | EBI | MGI Sequence Detail 509 Not Applicable
For the selected sequences
All sequences(40)
Alleles
and
phenotypes
All alleles(9) : Targeted, knock-out(3) Targeted, other(1) Gene trapped(4) Chemically induced(1)
Targeted mutations result in abnormal lipoprotein metablolism and, for one allele, reversible female infertility. An ENU mutant shows increased cholesterol levels.
Polymorphisms RFLP(1) SNPs within 2kb(193 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications(16)
Process blood vessel endothelial cell migration, cell adhesion...
Component caveola, integral to membrane...
Function high-density lipoprotein binding, receptor activity...
External Resources: MouseFunc
Expression Literature Summary: (11 records)
Data Summary: Assays (1)    Results (44)    Tissues (16)
Theiler Stages: 18,20,21,22
  Assay Type Assays   Results
      RT-PCR 1   44
cDNA source data(18)
External Resources: Allen Brain Atlas  GEO 
Molecular
reagents
All nucleic(21) cDNA(18) Primer pair(2) Other(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000037936
DoTS DT.536072, DT.94407272, DT.94407273, DT.97344626, DT.97392173
DFCI TC1572096, TC1589927, TC1590445
NIA Mouse Gene Index U026741
Entrez Gene 20778
VEGA Gene Model OTTMUSG00000022742
International Mouse Knockout Project Status Scarb1
Protein
domains
InterPro ID Description
IPR002159 CD36 antigen
IPR005428 Adhesion molecule CD36
Graphical View of Protein Domain Structure
References
(Earliest) J:37371 Acton SL et al., "Expression cloning of SR-BI, a CD36-related class B scavenger receptor." J Biol Chem 1994 Aug 19;269(33):21003-9
(Latest) J:152734 Guo L et al., "Scavenger Receptor BI Protects against Septic Death through Its Role in Modulating Inflammatory Response." J Biol Chem 2009 Jul 24;284(30):19826-34
All references(121)
Other
accession IDs
MGI:1196331, MGI:2140809, MGI:3575156

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/20/2009
MGI_4.31
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