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Cyp4a10 Gene Detail
 Symbol
Name
ID
Cyp4a10
cytochrome P450, family 4, subfamily a, polypeptide 10
MGI:88611


Nomenclature History
Synonyms Cyp4a, D4Rp1, RP1
Genetic Map
Chromosome 4
49.5 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 34)

Sequence Map
Chr4:115190869-115206254 bp, + strand
(From VEGA annotation of NCBI Build 37)
VEGA ContigView | Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Cyp4a10 ± 2 cM)
Protein SuperFamily: cytochrome P450 CYP4B1
TreeFam: TF105088
Sequences
Representative Sequences Length Strain/Species Flank
genomic OTTMUSG00000008614 VEGA Gene Model | MGI Sequence Detail 15386 C57BL/6J ± Kb
transcript NM_010011 RefSeq | MGI Sequence Detail 2096 C57BL/6
polypeptide O88833 UniProt | EBI | MGI Sequence Detail 509 Not Applicable
For the selected sequences
All sequences(22)
Alleles
and
phenotypes
All alleles(3) : Targeted, knock-out(2) Gene trapped(1)
Mice homozygous for a null mutation display salt-sensitive hypertension, decrease sodium excretion, and decreased urine output.
Polymorphisms RFLP(7) SNPs within 2kb(111 from dbSNP Build 128)   SNPs within 2kb including multiple locations(183)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process fatty acid metabolic process, oxidation reduction...
Component endoplasmic reticulum, membrane...
Function alkane 1-monooxygenase activity, electron carrier activity...
External Resources: FuncBase
Expression Literature Summary: (2 records)
Data Summary: Assays (1)    Results (12)    Tissues (12)
Theiler Stages: 10,18,23,25,28
  Assay Type Assays   Results
      RT-PCR 1   12
cDNA source data(10)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents
All nucleic(17) Genomic(4) cDNA(11) Primer pair(1) Other(1)
Microarray probesets(2)
Other database
links
EC 1.14.15.3
Ensembl Gene Model ENSMUSG00000066072
Consensus CDS Project CCDS18492.1
DFCI TC1579925, TC1595997, TC1643154
Entrez Gene 13117
VEGA Gene Model OTTMUSG00000008614
International Mouse Knockout Project Status Cyp4a10
Protein
domains
InterPro ID Description
IPR001128 Cytochrome P450
IPR002401 Cytochrome P450, E-class, group I
IPR017972 Cytochrome P450, conserved site
IPR017973 Cytochrome P450, C-terminal
Graphical View of Protein Domain Structure
References
(Earliest) J:13884 Elliott RW, "Identification and mapping of new loci using cloned cDNA." Mouse News Lett 1981;64():87
(Latest) J:121394 Muller DN et al., "Mouse Cyp4a isoforms: enzymatic properties, gender- and strain-specific expression, and role in renal 20-hydroxyeicosatetraenoic acid formation." Biochem J 2007 Apr 1;403(1):109-18
All references(39)
Other
accession IDs
MGD-MRK-14013, MGD-MRK-2333, MGD-MRK-2334, MGD-MRK-6982, MGI:2140347

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/06/2010
MGI_4.32
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The Jackson Laboratory