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Csnk2a2 Gene Detail
 Symbol
Name
ID
Csnk2a2
casein kinase 2, alpha prime polypeptide
MGI:88547


Nomenclature History
Synonyms 1110035J23Rik, CK2
Genetic Map
Chromosome 8
50.0 cM
Detailed Genetic Map ± 1 cM
 
Mapping data( 6)

Sequence Map
Chr8:97971872-98012690 bp, - strand
(From NCBI annotation of NCBI Build 37)
Ensembl ContigView | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
Mammalian
homology
human; chimpanzee; cattle; dog, domestic; rat    (Mammalian Orthology)
Comparative Map (Mouse/Human Csnk2a2 ± 2 cM)
Protein SuperFamily: kinase-related transforming protein
TreeFam: TF300483
Sequences
Representative Sequences Length Strain/Species Flank
genomic 13000 NCBI Gene Model | MGI Sequence Detail 40819 C57BL/6J ± Kb
transcript NM_009974 RefSeq | MGI Sequence Detail 3766 C57BL/6
polypeptide O54833 UniProt | EBI | MGI Sequence Detail 350 Not Applicable
For the selected sequences
All sequences(32)
Alleles
and
phenotypes
All alleles(10) : Targeted, knock-out(1) Gene trapped(9)
Males homozygotes for a targeted null mutation of the minor catalytic subunit exhibit infertility with oligospermia and abnormally shaped spermatid nuclei.
Associated Human Diseases (1)   Alleles Annotated to Human Diseases (1)  
Polymorphisms PCR(4) SNPs within 2kb(224 from dbSNP Build 128)  
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process protein amino acid phosphorylation, regulation of cell cycle...
Component protein kinase CK2 complex
Function ATP binding, kinase activity...
External Resources: FuncBase
Expression Literature Summary: (2 records)
Data Summary: Assays (1)    Results (93)    Tissues (93)    Images (17)
Theiler Stages: 22
  Assay Type Assays   Results
      RNA in situ 1   93
cDNA source data(18)
External Resources: Allen Brain Atlas  GEO  ArrayExpress 
Molecular
reagents
All nucleic(26) Genomic(1) cDNA(20) Primer pair(5)
Microarray probesets(8)
Other database
links
EC 2.7.11.1
Ensembl Gene Model ENSMUSG00000046707
DoTS DT.101737816, DT.530502
Consensus CDS Project CCDS22562.1
DFCI TC1577971, TC1604034, TC1643470
NIA Mouse Gene Index U030136, U364868
Entrez Gene 13000
International Mouse Knockout Project Status Csnk2a2
Protein
domains
InterPro ID Description
IPR000719 Protein kinase, catalytic domain
IPR002290 Serine/threonine-protein kinase domain
IPR008271 Serine/threonine-protein kinase, active site
IPR011009 Protein kinase-like domain
IPR017441 Protein kinase, ATP binding site
IPR017442 Serine/threonine-protein kinase-like domain
Graphical View of Protein Domain Structure
References
(Earliest) J:2617 Yang-Feng TL et al., "Mapping of the human casein kinase II catalytic subunit genes: two loci carrying the homologous sequences for the alpha subunit." Nucleic Acids Res 1991 Dec;19(25):7125-9
(Latest) J:147042 Maier B et al., "A large-scale functional RNAi screen reveals a role for CK2 in the mammalian circadian clock." Genes Dev 2009 Mar 15;23(6):708-18
All references(27)
Other
accession IDs
MGD-MRK-2205, MGI:1915939, MGI:2142847

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
02/06/2010
MGI_4.32
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